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BioChem, Volume 3, Issue 4

December 2023 - 3 articles

Cover Story: Our previous study has successfully outlined the phytochemical profile of various Indonesian betel quid (BQ) components and highlighted the potentially harmful effects in all BQ components tested. To explore the pathobiological effect of Indonesian BQ components, we employed a cytotoxicity test of fluorescein diacetate assay (FDA) to assess the cell viability of BQ components on oral keratinocyte and fibroblast cells. We selected BQ from Banda Aceh and West Papua as these possess the lowest and the highest levels of polyphenols and arecoline, respectively. We specifically aimed to probe whether the pathobiological effect of BQ on oral mucosal cells corresponds with its phytochemical profile. View this paper

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Review

2 Citations

3,461 Views

15 Pages

Role of MOB4 in Cell Proliferation and Neurogenesis

Inês B. Santos,
Juan Garrido-Maraver,
Carolina Gonçalves,
Bruna I. Oliveira and
Álvaro A. Tavares

BioChem2023, 3(4), 182-196;https://doi.org/10.3390/biochem3040013

6 December 2023

Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that parti...

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Article

2,666 Views

12 Pages

Metabolic Effects on Mouse Embryonic Stem Cells and the Canonical Mammalian Target of Rapamycin Pathway

Bibiana Correia,
Maria Inês Sousa and
João Ramalho-Santos

BioChem2023, 3(4), 170-181;https://doi.org/10.3390/biochem3040012

9 November 2023

Diapause-like features can be extended to naïve mouse embryonic stem cells (mESCs) to induce paused pluripotency by using INK128 (mTi), a mammalian target of rapamycin (mTOR) inhibitor. As a core integrative pathway, mTOR senses diverse stimuli...

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Article

1 Citations

2,860 Views

17 Pages

Cytotoxic Effects of Indonesian Betel Quid Components on Oral Keratinocytes and Fibroblasts

Elizabeth Fitriana Sari,
Ali I. Mohammed,
Antonio Celentano,
Michael John McCullough and
Nicola Cirillo

BioChem2023, 3(4), 153-169;https://doi.org/10.3390/biochem3040011

23 October 2023

A betel quid (BQ) chewing habit has been strongly associated with the development of several oral mucosal diseases. In order to investigate whether individual components of BQ mixtures have distinct physio-pathological effects on oral mucosal cells,...

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