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BioTech, Volume 13, Issue 1

March 2024 - 7 articles

Cover Story: Gene therapy holds promise as a life-changing option for individuals with genetic variants. FDA-approved gene therapies have generated buzz around the ability to change the course of genetic syndromes. However, this excitement risks over-expansion into areas of genetic disease that may not fit the current state of gene therapy. It is critical to evaluate the field of genetic diseases relative to the continued risks of delivery systems and foreign RNA, performing cost–benefit analyses for each gene therapy use. Within the work by Henderson et al., they present the current state while setting forth tools and resources to guide informed directions to avoid foreseeable issues in gene therapy that could prevent continued success in the field. View this paper
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Articles (7)

  • Article
  • Open Access
8 Citations
3,446 Views
14 Pages

Optimization of Aqueous Extraction of Polyphenols from Cuminum cyminum Seeds Using Response Surface Methodology and Assessment of Biological Activity

  • Hana El Tannir,
  • Diana Houhou,
  • Espérance Debs,
  • Mohamed Koubaa,
  • Adla Jammoul,
  • Bilal Azakir,
  • Mahmoud I. Khalil,
  • Nada El Darra and
  • Nicolas Louka

21 March 2024

(1) Background: Cumin seeds, extracted from the plant Cuminum cyminum, are abundant in phenolic compounds and have been extensively researched for their chemical makeup and biological effects. The objective of this research is to enhance the water ex...

  • Article
  • Open Access
6 Citations
2,625 Views
11 Pages

Chitosan, a natural cationic polysaccharide derived from crustaceans and shellfish shells, is known for its advantageous biological properties, including biodegradability, biocompatibility, and antibacterial activity. Chitosan and its composite mater...

  • Article
  • Open Access
4 Citations
2,537 Views
22 Pages

20 February 2024

Tetranychus urticae Koch, a phytophagous mite, is one of the most significant crop pests globally. The primary method employed for controlling T. urticae involves chemical means, utilizing synthesized products, posing the risk of developing resistanc...

  • Article
  • Open Access
3 Citations
2,450 Views
31 Pages

7 February 2024

Glycosyltransferases (GTs) are pivotal enzymes in the biosynthesis of various biological molecules. This study focuses on the scale-up, expression, and purification of a plant flavonol-specific 3-O glucosyltransferase (Cp3GT), a key enzyme from Citru...

  • Review
  • Open Access
18 Citations
20,043 Views
12 Pages

Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights

  • Jiawei Chen,
  • Ravi Potlapalli,
  • Heng Quan,
  • Lingtao Chen,
  • Ying Xie,
  • Seyedamin Pouriyeh,
  • Nazmus Sakib,
  • Lichao Liu and
  • Yixin Xie

16 January 2024

DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders. DNA repair mechanisms play a pivotal role in safeguarding genetic integrity...

  • Article
  • Open Access
3 Citations
4,017 Views
12 Pages

Styrene Production in Genetically Engineered Escherichia coli in a Two-Phase Culture

  • Shuhei Noda,
  • Ryosuke Fujiwara,
  • Yutaro Mori,
  • Mayumi Dainin,
  • Tomokazu Shirai and
  • Akihiko Kondo

14 January 2024

Styrene is an important industrial chemical. Although several studies have reported microbial styrene production, the amount of styrene produced in batch cultures can be increased. In this study, styrene was produced using genetically engineered Esch...

  • Review
  • Open Access
21 Citations
28,098 Views
31 Pages

Gene Therapy for Genetic Syndromes: Understanding the Current State to Guide Future Care

  • Marian L. Henderson,
  • Jacob K. Zieba,
  • Xiaopeng Li,
  • Daniel B. Campbell,
  • Michael R. Williams,
  • Daniel L. Vogt,
  • Caleb P. Bupp,
  • Yvonne M. Edgerly,
  • Surender Rajasekaran and
  • Nicholas L. Hartog
  • + 2 authors

3 January 2024

Gene therapy holds promise as a life-changing option for individuals with genetic variants that give rise to disease. FDA-approved gene therapies for Spinal Muscular Atrophy (SMA), cerebral adrenoleukodystrophy, β-Thalassemia, hemophilia A/B, re...

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BioTech - ISSN 2673-6284Creative Common CC BY license