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BioTech, Volume 11, Issue 1

March 2022 - 7 articles

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Cover Story: The possibility of targeting pathogens at their entry points can consolidate protective immunity. Regarding SARS-CoV-2 infection, it has been observed that the dysregulation of resident microbiota in the gut–lung axis plays a crucial role in determining severity. Thus, understanding the possibility of eliciting various mucosal and adaptive immune responses allows us to effectively design bacterial mucosal vaccine vectors. Such design requires rationally selecting resident bacterial candidates as host carriers, evaluating effective carrier proteins for stimulating an immune response, and combining these to improve antigenic display and immunogenicity. Current literature is still lacking beyond in vitro or in vivo efficiency, but decades of research into these vectors show promising results. View this paper

Articles (7)

  • Article
  • Open Access
5 Citations
3,384 Views
15 Pages

High Performance Integration Pipeline for Viral and Epitope Sequences

  • Tommaso Alfonsi,
  • Pietro Pinoli and
  • Arif Canakoglu

21 March 2022

With the spread of COVID-19, sequencing laboratories started to share hundreds of sequences daily. However, the lack of a commonly agreed standard across deposition databases hindered the exploration and study of all the viral sequences collected wor...

  • Review
  • Open Access
32 Citations
8,464 Views
24 Pages

Non-Viral Vectors for Delivery of Nucleic Acid Therapies for Cancer

  • Shrey Kanvinde,
  • Tanmay Kulkarni,
  • Suyash Deodhar,
  • Deep Bhattacharya and
  • Aneesha Dasgupta

The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid t...

  • Review
  • Open Access
31 Citations
9,574 Views
20 Pages

A Systematic Review of Oral Biopsies, Sample Types, and Detection Techniques Applied in Relation to Oral Cancer Detection

  • Guanghuan Yang,
  • Luqi Wei,
  • Benjamin K. S. Thong,
  • Yuanyuan Fu,
  • Io Hong Cheong,
  • Zisis Kozlakidis,
  • Xue Li,
  • Hui Wang and
  • Xiaoguang Li

Background: Early identification of the stage of oral cancer development can lead to better treatment outcomes and avoid malignant transformation. Therefore, this review aims to provide a comprehensive overview that describes the development of stand...

  • Article
  • Open Access
7 Citations
6,730 Views
9 Pages

24 February 2022

Ethidium bromide (EtBr) is widely used in most laboratories to detect nucleic acids in gel electrophoresis applications. It is a well-known carcinogenic and mutagenic agent, which can affect biotic components of the place in which it is disposed. Usu...

  • Review
  • Open Access
7 Citations
6,425 Views
18 Pages

30 January 2022

Infectious diseases caused by mucosal pathogens significantly increase mortality and morbidity. Thus, the possibility to target these pathogens at their primary entry points can consolidate protective immunity. Regarding SARS-CoV-2 infection, it has...

  • Article
  • Open Access
7 Citations
6,048 Views
16 Pages

14 January 2022

The purpose of this paper is to elucidate the roles that microbes may be playing in the rootzone of the medicinal plant Daturainoxia. We hypothesized that the microbes associated with the Datura rootzone would be significantly different than the simi...