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Immuno, Volume 3, Issue 4

2023 December - 2 articles

Cover Story: Liver fibrosis is a complex, dynamic process associated with a broad spectrum of chronic and acute liver diseases. It is defined by the dysregulated intrahepatic production of extracellular matrix proteins, replacing functional liver cells with scar tissue, resulting in cirrhosis and liver failure. Despite the global burden of the disease, no existing therapies can treat or reverse hepatic fibrosis. In this review, we summarise the current understanding of the intricate inflammatory network central to liver fibrogenesis, with a focus on the role of regulatory T cells. We also discuss the advancements in therapeutics, including T cell immunotherapies, which show promise as effective treatments for liver fibrosis. Further work is required to better define the function of immune cells in fibrosis to enable the rationale design of better treatments. View this paper
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Articles (2)

  • Review
  • Open Access
10 Citations
7,313 Views
34 Pages
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Inflammatory Network of Liver Fibrosis and How It Can Be Targeted Therapeutically

  • Kirstin O. Lowe,
  • Constantin E. Tanase,
  • Susan Maghami,
  • Leanne E. Fisher and
  • Amir M. Ghaemmaghami
Immuno2023, 3(4), 375-408;https://doi.org/10.3390/immuno3040023

28 November 2023

Liver fibrosis is a complex, dynamic process associated with a broad spectrum of chronic liver diseases and acute liver failure, characterised by the dysregulated intrahepatic production of extracellular matrix proteins replacing functional liver cel...

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  • Article
  • Open Access
2,489 Views
17 Pages
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High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection

  • Caitlin A. Williams,
  • Teri Ann S. Wong,
  • Michael M. Lieberman,
  • Jake Yalley-Ogunro,
  • Mehtap Cabus,
  • Sara Nezami,
  • Fabian Paz,
  • Hanne Andersen,
  • Thomas W. Geisbert and
  • Axel T. Lehrer
Immuno2023, 3(4), 358-374;https://doi.org/10.3390/immuno3040022

24 October 2023

Zaire ebolavirus (EBOV) poses a significant threat to public health due to its high case fatality rate and epidemic potential. This is further complicated by the lack of precise immune correlates of protection and difficulties in conducting in vivo a...

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