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9 pages, 2889 KiB

Open AccessProceeding Paper

An Electrochemical Sensing Platform Based on a Carbon Paste Electrode Modified with a Graphene Oxide/TiO₂ Nanocomposite for Atenolol Determination

by Ergi Hoxha, Nevila Broli, Majlinda Vasjari and Sadik Cenolli

Eng. Proc. 2024, 73(1), 1; https://doi.org/10.3390/engproc2024073001 - 19 Aug 2024

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Abstract

Atenolol is a medication belonging to the class of drugs known as beta-blockers, used to treat high blood pressure (hypertension) and irregular heartbeats (arrhythmia). Their presence in the environment has serious impacts on humans, animals, and the water ecosystem. In this context, the aim of this study was to develop a simple voltammetric method for the determination of atenolol (ATN) using carbon paste electrodes modified with the nanomaterials TiO₂ and rGO/TiO₂. The analytical performance of the modified sensor was evaluated using square wave voltammetry and cyclic voltammetry in 0.1 mol L⁻¹ acid sulfuric solution (H₂SO₄), pH 2. The nanocomposite electrode CPE/rGO/TiO₂ exhibited excellent electrocatalytic activity towards ATN oxidations at 0.1 mol L⁻¹ H₂SO₄ compared with unmodified carbon paste electrodes CPEs and those modified with titanium oxide, CPE/TiO₂. Different experimental and conditional parameters were optimized, such as supporting electrolytes, pH, amplitude, frequency, etc. Under optimal conditions, linear calibration curves were obtained, ranging from 1.7 to 23.2 µmol L⁻¹ for ATN with detection limits of 0.05 μmol L⁻¹. The modified nanocomposite CPE/rGO/TiO₂ sensor showed good sensitivity and good repeatability (RSD ≤ 0.61%) for ATN determination. The proposed sensor is mechanically robust and presented reproducible results and a long useful life. In order to verify the usefulness of the developed methods, the nanocomposite sensor CPE/rGO/TiO₂ was applied for the detection of atenolol in real samples (pharmaceutical tablets without any pre-treatment). The excipients present in the tablets did not interfere in the assay. Recoveries ranging from 97.7% to 106% were obtained. The results showed that the CPE/rGO/TiO₂ voltammetric sensor could be successfully applied in the routine quality control of ATN in complex matrices. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Biosensors)

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9 pages, 2729 KiB

Open AccessProceeding Paper

Development of a Flexible Piezoelectric Biosensor That Integrates BaTiO₃–Poly(Dimethylsiloxane) for Posture Correction Applications

by Menduh Furkan Aslan, Cem Özbek, Gökhan Yiğit, Mehmet Tosun and Seda Demirel Topel

Eng. Proc. 2024, 73(1), 2; https://doi.org/10.3390/engproc2024073002 - 20 Sep 2024

Abstract

The prolonged issue of poor posture due to desk work has led to innovative technological remedies. This study shows the development of a flexible piezoelectric biosensor integrating BaTiO₃ nanoparticles within a Polydimethylsiloxane (PDMS) matrix for practical posture correction. The biosensor is capable of real-time posture monitoring and correction by leveraging the piezoelectric properties of BaTiO₃. Comprehensive synthesis and characterization using X-ray diffraction analysis (XRD) and transmission electron microscopy (TEM) validated the ideal particle size and crystalline structure of the composite. COMSOL Multiphysics simulations showed a peak potential of 0.87 volts under mechanical stress, which further confirmed the sensor’s efficiency. Electrical testing revealed that the sensor with 35 wt.% BaTiO₃ exhibited a higher output voltage of 0.87 V compared to 0.34 V for the sensor with 30 wt.% BaTiO₃, emphasizing its exceptional potential for addressing posture-related issues. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Biosensors)

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5 pages, 928 KiB

Open AccessProceeding Paper

ZnO Functional Nanomaterial in Green Microalgae Growth Advancement

by Praskoviya Boltovets, Sergii Kravchenko and Viktoriya Petlovana

Eng. Proc. 2024, 73(1), 3; https://doi.org/10.3390/engproc2024073003 - 8 Oct 2024

Abstract

Nanomaterials are substances with unique properties due to the irintrinsic confinement effect and high surface area that have allowed their use in biology and medicine for sensor application. The key feature of nanomaterials in such applications is their ability to providesensitivity enhancement for sensors. On the other hand, nanomaterials possess the ability to change the biological function in cells or tissues; therefore, it is from this point of view that nanomaterials can be considered as functional. As far as biosensor application is concerned, it is important to optimize the determination of target molecules in spatial and temporal modes. The purpose of the presented work was to study the effect of functional nanomaterials on the growth (the temporal component) and morphology (the spatial component) of cell culture. The aim was to provide a culture condition where an increase in both the spatial and temporal components of configuration could be achieved in order to optimize sensor needs. Since microalgae have a wide range of possibilities for practical use in medicine, pharmacology and various industries, the study of the effect of nanomaterials on their growth and development is very important. It was found that ZnO nanomaterial, which was obtained by volumetric electrospark dispersion, revealed the concentration-dependent effect on both the grown rate and the color intensity interior of Chlamydomonas monadina microalgae culture. Therefore, ZnO functional nanomaterial achieved the optimization of target molecule formation for biosensor application. Full article

(This article belongs to the Proceedings of The 4th International Electronic Conference on Biosensors)

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