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Livers, Volume 5, Issue 1

2025 March - 14 articles

Cover Story: Transarterial chemoembolization (TACE) is the most widely used bridging treatment for hepatocellular carcinoma (HCC) before liver transplantation (LT) but may be associated with dropout and post-LT HCC recurrence. This article aimed to identify a subgroup of HCC LT candidates at high risk of TACE-to-LT strategy failure (TLSF). All consecutive HCC LT candidates with French AFP-scores ≤ 2 who underwent at least one bridging TACE at Paul Brousse Hospital in 2013–2018 were included (n = 173). Dropout for HCC progression during waiting list and post-LT HCC recurrence was defined TLSF. HCC patients receiving bridging TACE, with pre-TACE AFP > 15 ng/mL and no CRR after two TACEs, are at high risk of delisting for HCC progression or of post-LT recurrence. Alternative therapeutic strategies should be proposed early for this better-defined population. View this paper
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Articles (14)

  • Review
  • Open Access
7 Citations
4,469 Views
21 Pages

AI Innovations in Liver Transplantation: From Big Data to Better Outcomes

  • Eleni Avramidou,
  • Dominik Todorov,
  • Georgios Katsanos,
  • Nikolaos Antoniadis,
  • Athanasios Kofinas,
  • Stella Vasileiadou,
  • Konstantina-Eleni Karakasi and
  • Georgios Tsoulfas

14 March 2025

Artificial intelligence (AI) has emerged as a transformative field in computational research with diverse applications in medicine, particularly in the field of liver transplantation (LT) given its ability to analyze and build upon complex and multid...

  • Case Report
  • Open Access
3 Citations
5,005 Views
9 Pages

13 March 2025

Introduction: We describe the first reported case of auto-brewery syndrome complicating liver transplantation, wherein a patient was temporarily removed from a liver transplant list not due to ethanol consumption but rather spontaneous ethanolic ferm...

  • Article
  • Open Access
2 Citations
2,676 Views
15 Pages

A Metabolomics-Based Approach for Diagnosing NAFLD and Identifying Its Pre-Condition Along the Potential Disease Spectrum

  • Masanori Nojima,
  • Takeshi Kimura,
  • Yutaka Aoki,
  • Hirotaka Fujimoto,
  • Kuniyoshi Hayashi,
  • Junya Ohtake,
  • Mariko Kimura-Asami,
  • Kazuhiko Suzuki,
  • Kevin Urayama and
  • Katsunori Masuda
  • + 2 authors

12 March 2025

Introduction: The significant impact of nonalcoholic fatty liver disease (NAFLD) on public health, combined with the limitations of current diagnostic approaches, demands a more comprehensive and accurate method to identify NAFLD cases in large gener...

  • Review
  • Open Access
15 Citations
10,021 Views
33 Pages

Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Pathogenic Mechanisms and Therapeutic Implications

  • Farah Abdelhameed,
  • Attia Mustafa,
  • Chris Kite,
  • Lukasz Lagojda,
  • Alexander Dallaway,
  • Nwe Ni Than,
  • Eva Kassi,
  • Ioannis Kyrou and
  • Harpal S. Randeva

4 March 2025

Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common cause of chronic liver disease worldwide. Characterized by excessive hepatic fat accumulation, this...

  • Article
  • Open Access
1,433 Views
15 Pages

Identifying Subgroup at High Risk of Transarterial Chemoembolization Failure Among Patients with Hepatocellular Carcinoma Awaiting Liver Transplantation

  • Edoardo Poli,
  • Marc-Antoine Allard,
  • Astrid Laurent-Bellue,
  • Maïté Lewin,
  • Catherine Guettier,
  • Daniel Azoulay,
  • Audrey Coilly,
  • Alexandre Dos Santos,
  • Jamila Faivre and
  • Olivier Rosmorduc
  • + 9 authors

20 February 2025

Background/Objectives: Transarterial chemoembolization (TACE) is the most widely used bridging treatment for hepatocellular carcinoma (HCC) before liver transplantation (LT) but may be associated with dropout and post-LT HCC recurrence. We aimed to i...

  • Review
  • Open Access
8 Citations
3,386 Views
21 Pages

14 February 2025

Conventionally, drug-induced liver injury (DILI) exists in two types: idiosyncratic and intrinsic. Both types are classified as non-immune disorders, thereby ignoring that some iDILI cases may have an immune or autoimmune background that requires a d...

  • Review
  • Open Access
1 Citations
3,770 Views
11 Pages

Changes and Future Directions in Liver Transplantation in the United States

  • Francis Spitz,
  • Stalin Dharmayan,
  • Jason Mial-Anthony,
  • Abiha Abdullah,
  • Charbel Elias,
  • Godwin Packiaraj,
  • Sabin Subedi and
  • Michele Molinari

8 February 2025

Liver transplantation (LT) in the United States is evolving in response to shifting disease patterns, innovative therapies, and technological advancements. Metabolic-associated fatty liver disease (MAFLD) and alcohol-associated liver disease (ALD) no...

  • Review
  • Open Access
1 Citations
3,301 Views
12 Pages

Electrochemotherapy for Colorectal Liver Metastasis: What Interventional Radiologists Need to Know

  • Alessandro Posa,
  • Pierluigi Barbieri,
  • Marcello Lippi,
  • Alessandro Maresca,
  • Edoardo Vincenzo Andreani and
  • Roberto Iezzi

7 February 2025

The global burden of liver metastases from different primary lesions is increasing, resulting in significant challenges for public health systems. Accordingly, colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with a high i...

  • Review
  • Open Access
6 Citations
5,972 Views
58 Pages

Immune Checkpoints and the Immunology of Liver Fibrosis

  • Ioannis Tsomidis,
  • Argyro Voumvouraki and
  • Elias Kouroumalis

27 January 2025

Liver fibrosis is a very complicated dynamic process where several immune cells are involved. Both innate and adaptive immunity are implicated, and their interplay is always present. Multi-directional interactions between liver macrophages, hepatic s...

  • Review
  • Open Access
9 Citations
14,532 Views
17 Pages

23 January 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the novel terminology encompassing liver disease associated with metabolic dysfunction, replacing the previous terminology of non-alcoholic fatty liver disease (NAFLD). This disease...

  • Article
  • Open Access
1,720 Views
27 Pages

Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model

  • Dariusz Pyka,
  • Agnieszka Noszczyk-Nowak,
  • Karina Krawiec,
  • Tomasz Świetlik and
  • Krzysztof J. Opieliński

16 January 2025

The authors of this study focused their research on developing cap geometries for the FibroScan® elastograph (FibroScan, EchoSens, Paris, France) measuring head aimed at a non-invasive assessment of liver condition for transplantation using a pig...

  • Article
  • Open Access
1 Citations
2,955 Views
18 Pages

Advancing Chronic Liver Disease Diagnoses: Targeted Proteomics for the Non-Invasive Detection of Fibrosis

  • Andrea Villanueva Raisman,
  • David Kotol,
  • Ozlem Altay,
  • Adil Mardinoglu,
  • Dila Atak,
  • Cihan Yurdaydin,
  • Murat Akyildiz,
  • Murat Dayangac,
  • Hale Kirimlioglu and
  • Fredrik Edfors
  • + 1 author

14 January 2025

Chronic liver disease poses significant challenges to healthcare systems, which frequently struggle to meet the needs of end-stage liver disease patients. Early detection and management are essential because liver damage and fibrosis are potentially...

  • Article
  • Open Access
3,864 Views
26 Pages

31 December 2024

Background: This study addresses a particular aspect of the biological behavior of the Spike subunit S1 of SARS-CoV-2. Researchers observed S1 acting freely in the human organism during and after COVID-19 and vaccination. One of its properties is tha...

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Livers - ISSN 2673-4389