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Livers, Volume 5, Issue 1

2025 March - 14 articles

Cover Story: Transarterial chemoembolization (TACE) is the most widely used bridging treatment for hepatocellular carcinoma (HCC) before liver transplantation (LT) but may be associated with dropout and post-LT HCC recurrence. This article aimed to identify a subgroup of HCC LT candidates at high risk of TACE-to-LT strategy failure (TLSF). All consecutive HCC LT candidates with French AFP-scores ≤ 2 who underwent at least one bridging TACE at Paul Brousse Hospital in 2013–2018 were included (n = 173). Dropout for HCC progression during waiting list and post-LT HCC recurrence was defined TLSF. HCC patients receiving bridging TACE, with pre-TACE AFP > 15 ng/mL and no CRR after two TACEs, are at high risk of delisting for HCC progression or of post-LT recurrence. Alternative therapeutic strategies should be proposed early for this better-defined population. View this paper
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Articles (14)

  • Review
  • Open Access
9 Citations
6,117 Views
21 Pages

AI Innovations in Liver Transplantation: From Big Data to Better Outcomes

  • Eleni Avramidou,
  • Dominik Todorov,
  • Georgios Katsanos,
  • Nikolaos Antoniadis,
  • Athanasios Kofinas,
  • Stella Vasileiadou,
  • Konstantina-Eleni Karakasi and
  • Georgios Tsoulfas

14 March 2025

Artificial intelligence (AI) has emerged as a transformative field in computational research with diverse applications in medicine, particularly in the field of liver transplantation (LT) given its ability to analyze and build upon complex and multid...

  • Case Report
  • Open Access
5 Citations
7,106 Views
9 Pages

13 March 2025

Introduction: We describe the first reported case of auto-brewery syndrome complicating liver transplantation, wherein a patient was temporarily removed from a liver transplant list not due to ethanol consumption but rather spontaneous ethanolic ferm...

(This article belongs to the Special Issue Recent Advances in the Detection and Pathophysiology of Steatotic, Alcoholic and Drug-Induced Liver Diseases)
  • Article
  • Open Access
3 Citations
3,912 Views
15 Pages

A Metabolomics-Based Approach for Diagnosing NAFLD and Identifying Its Pre-Condition Along the Potential Disease Spectrum

  • Masanori Nojima,
  • Takeshi Kimura,
  • Yutaka Aoki,
  • Hirotaka Fujimoto,
  • Kuniyoshi Hayashi,
  • Junya Ohtake,
  • Mariko Kimura-Asami,
  • Kazuhiko Suzuki,
  • Kevin Urayama and
  • Katsunori Masuda
  • + 2 authors

12 March 2025

Introduction: The significant impact of nonalcoholic fatty liver disease (NAFLD) on public health, combined with the limitations of current diagnostic approaches, demands a more comprehensive and accurate method to identify NAFLD cases in large gener...

  • Review
  • Open Access
29 Citations
14,822 Views
33 Pages

Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Pathogenic Mechanisms and Therapeutic Implications

  • Farah Abdelhameed,
  • Attia Mustafa,
  • Chris Kite,
  • Lukasz Lagojda,
  • Alexander Dallaway,
  • Nwe Ni Than,
  • Eva Kassi,
  • Ioannis Kyrou and
  • Harpal S. Randeva

4 March 2025

Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common cause of chronic liver disease worldwide. Characterized by excessive hepatic fat accumulation, this...

  • Article
  • Open Access
1,749 Views
15 Pages

Identifying Subgroup at High Risk of Transarterial Chemoembolization Failure Among Patients with Hepatocellular Carcinoma Awaiting Liver Transplantation

  • Edoardo Poli,
  • Marc-Antoine Allard,
  • Astrid Laurent-Bellue,
  • Maïté Lewin,
  • Catherine Guettier,
  • Daniel Azoulay,
  • Audrey Coilly,
  • Alexandre Dos Santos,
  • Jamila Faivre and
  • Olivier Rosmorduc
  • + 9 authors

20 February 2025

Background/Objectives: Transarterial chemoembolization (TACE) is the most widely used bridging treatment for hepatocellular carcinoma (HCC) before liver transplantation (LT) but may be associated with dropout and post-LT HCC recurrence. We aimed to i...

  • Review
  • Open Access
11 Citations
5,135 Views
21 Pages

14 February 2025

Conventionally, drug-induced liver injury (DILI) exists in two types: idiosyncratic and intrinsic. Both types are classified as non-immune disorders, thereby ignoring that some iDILI cases may have an immune or autoimmune background that requires a d...

  • Review
  • Open Access
3 Citations
5,244 Views
11 Pages

Changes and Future Directions in Liver Transplantation in the United States

  • Francis Spitz,
  • Stalin Dharmayan,
  • Jason Mial-Anthony,
  • Abiha Abdullah,
  • Charbel Elias,
  • Godwin Packiaraj,
  • Sabin Subedi and
  • Michele Molinari

8 February 2025

Liver transplantation (LT) in the United States is evolving in response to shifting disease patterns, innovative therapies, and technological advancements. Metabolic-associated fatty liver disease (MAFLD) and alcohol-associated liver disease (ALD) no...

  • Review
  • Open Access
1 Citations
4,442 Views
12 Pages

Electrochemotherapy for Colorectal Liver Metastasis: What Interventional Radiologists Need to Know

  • Alessandro Posa,
  • Pierluigi Barbieri,
  • Marcello Lippi,
  • Alessandro Maresca,
  • Edoardo Vincenzo Andreani and
  • Roberto Iezzi

7 February 2025

The global burden of liver metastases from different primary lesions is increasing, resulting in significant challenges for public health systems. Accordingly, colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with a high i...

  • Review
  • Open Access
11 Citations
8,053 Views
58 Pages

Immune Checkpoints and the Immunology of Liver Fibrosis

  • Ioannis Tsomidis,
  • Argyro Voumvouraki and
  • Elias Kouroumalis

27 January 2025

Liver fibrosis is a very complicated dynamic process where several immune cells are involved. Both innate and adaptive immunity are implicated, and their interplay is always present. Multi-directional interactions between liver macrophages, hepatic s...

(This article belongs to the Special Issue Liver Fibrosis: Mechanisms, Targets, Assessment and Treatment)
  • Review
  • Open Access
12 Citations
19,393 Views
17 Pages

23 January 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the novel terminology encompassing liver disease associated with metabolic dysfunction, replacing the previous terminology of non-alcoholic fatty liver disease (NAFLD). This disease...

  • Article
  • Open Access
2,221 Views
27 Pages

Innovative Elastography Measuring Cap for Ex Vivo Liver Condition Assessment: Numerical and Preclinical Studies in a Porcine Model

  • Dariusz Pyka,
  • Agnieszka Noszczyk-Nowak,
  • Karina Krawiec,
  • Tomasz Świetlik and
  • Krzysztof J. Opieliński

16 January 2025

The authors of this study focused their research on developing cap geometries for the FibroScan® elastograph (FibroScan, EchoSens, Paris, France) measuring head aimed at a non-invasive assessment of liver condition for transplantation using a pig...

(This article belongs to the Special Issue Liver Fibrosis: Mechanisms, Targets, Assessment and Treatment)
  • Article
  • Open Access
1 Citations
4,321 Views
18 Pages

Advancing Chronic Liver Disease Diagnoses: Targeted Proteomics for the Non-Invasive Detection of Fibrosis

  • Andrea Villanueva Raisman,
  • David Kotol,
  • Ozlem Altay,
  • Adil Mardinoglu,
  • Dila Atak,
  • Cihan Yurdaydin,
  • Murat Akyildiz,
  • Murat Dayangac,
  • Hale Kirimlioglu and
  • Fredrik Edfors
  • + 1 author

14 January 2025

Chronic liver disease poses significant challenges to healthcare systems, which frequently struggle to meet the needs of end-stage liver disease patients. Early detection and management are essential because liver damage and fibrosis are potentially...

(This article belongs to the Special Issue Liver Fibrosis: Mechanisms, Targets, Assessment and Treatment)
  • Article
  • Open Access
1 Citations
4,826 Views
26 Pages

31 December 2024

Background: This study addresses a particular aspect of the biological behavior of the Spike subunit S1 of SARS-CoV-2. Researchers observed S1 acting freely in the human organism during and after COVID-19 and vaccination. One of its properties is tha...

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Livers - ISSN 2673-4389