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Endocrines, Volume 5, Issue 3
September 2024 - 16 articles
Cover Story: The adrenal gland is composed of the steroid hormone-secreting cortex and the catecholamine-secreting medulla. Various benign and malignant tumors originate from its distinct layers, among them the highly malignant adrenocortical carcinoma (ACC), arising from the secretory cells of the adrenal cortex, and pheochromocytoma (PCC), originating from the chromaffin cells of the adrenal medulla. ACCs are often diagnosed at advanced and metastatic stages, while PCCs are mostly benign with a malignancy rate of around 10%, strongly dependent on genetic/molecular characteristics. In recent years, novel preclinical murine and human cell line models have been established that better reflect the complexities of both tumor entities. View this paper
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Endocrines - ISSN 2673-396X