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Endocrines, Volume 5, Issue 2

June 2024 - 9 articles

Cover Story: Daily administered basal insulin analogs have been a cornerstone of multiple daily injection therapy for type 1 diabetes (T1D). Recently, once-weekly basal insulin analogs have been developed. Their extended action is based upon their binding to albumin and their gradual release into the bloodstream. Data for adult patients with T1D are limited, and none exist for pediatric or adolescent patients. Nevertheless, studies suggest that these analogs are safe and effective, benefiting those who miss doses or prefer fewer injections. They may reduce diabetic ketoacidosis risk and aid patients who struggle with diabetes devices. Further research is needed to address clinical questions about initiation, titration, and special situations like sick day management, especially in children and adolescents with T1D. View this paper
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Articles (9)

  • Brief Report
  • Open Access
2,300 Views
8 Pages

11 June 2024

Background: Pregestational diabetes mellitus, if not well controlled, determines maternal and fetal complications. According to the new diagnostic criteria for gestational diabetes, the diagnosis of diabetes mellitus can also occur in early pregnancy...

  • Review
  • Open Access
3 Citations
12,202 Views
19 Pages

Resveratrol Effects on Metabolic Syndrome Features: A Systematic Review and Meta-Analysis

  • Gislaine C. Batista-Jorge,
  • Antônio S. Barcala-Jorge,
  • Deborah F. Lelis,
  • Daniel E. Santos,
  • Antônio H. Jorge,
  • Renato S. Monteiro-Junior and
  • Sérgio H. S. Santos

22 May 2024

Resveratrol is a natural polyphenol with important anti-inflammatory and antioxidant properties for treating cardiometabolic disorders. Therefore, the present meta-analysis aimed to review and investigate the oral resveratrol supplementation effects...

  • Review
  • Open Access
3,122 Views
11 Pages

Which Diabetes Patients Will Benefit the Most from Once-Weekly Basal Insulin Analogs? A Review with a Special Focus on Type 1 Diabetes Patients

  • Chrysoula Kosmeri,
  • Maria Baltogianni,
  • Vasileios Giapros,
  • Ekaterini Siomou,
  • Vasiliki-Regina Tsinopoulou,
  • Foteini Balomenou and
  • Anastasios Serbis

Basal insulin analogs, typically administered once or twice daily, have been one of the two pillars of the multiple daily injection (MDI) insulin therapy of patients with type 1 diabetes (T1D) for the last twenty years. Recently, once-weekly basal in...

  • Article
  • Open Access
1 Citations
6,059 Views
17 Pages

Biomarkers of Neurodegeneration and Alzheimer’s Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study

  • Allison L. B. Shapiro,
  • Christina Coughlan,
  • Brianne M. Bettcher,
  • Meghan E. Pauley,
  • Jeongchul Kim,
  • Petter Bjornstad,
  • Benjamin Rajic,
  • Jennifer Truong,
  • Christopher Bell and
  • Ye Ji Choi
  • + 5 authors

Adult-onset diabetes increases one’s risk of neurodegenerative disease including Alzheimer’s disease (AD); however, the risk associated with youth-onset diabetes (Y-DM) remains underexplored. We quantified plasma biomarkers of neurodegene...

  • Article
  • Open Access
4,407 Views
11 Pages

Increased Psychological Symptoms and Autonomic Arousal in Patients with Subclinical Hypothyroidism: A Case–Control Study

  • Sara Guidotti,
  • Augusto Innocenti,
  • Chiara Cosentino,
  • Fabio Monzani,
  • Irene Guccini and
  • Carlo Pruneti

26 April 2024

(1) Background: Subclinical hypothyroidism (SHT) is a condition that has been a subject of controversy in the literature due to its association with psychological and psychiatric symptoms as well as autonomic imbalances. To gain a better understandin...

  • Article
  • Open Access
2 Citations
3,408 Views
20 Pages

Male LEW.1WR1 Rats Develop Metabolic Dysfunction, Steatohepatitis, and Liver Damage

  • Quiana C. Wilkerson-Vidal,
  • Madushika M. Wimalarathne,
  • Emily C. Hunt,
  • Luis Mercado,
  • Moses Adaji David,
  • Christopher R. Apperson,
  • Alan Smiley,
  • Sharifa Tahirah Love-Rutledge and
  • Bernhard W. G. Vogler

19 April 2024

Most patients with non-alcoholic steatohepatitis (NASH) have insulin resistance, and there is a near-universal association between NASH and insulin resistance. Insulin resistance induces lipid accumulation in the liver, leading to the development of...

  • Review
  • Open Access
21 Citations
15,001 Views
13 Pages

17 April 2024

Introduction: Insulin resistance is a common condition affecting thousands of people worldwide. This paper aims to examine the mechanisms underlying insulin resistance among people suffering from obesity. Methods and Design: This study entailed ident...

  • Article
  • Open Access
4 Citations
5,228 Views
16 Pages

Evaluation of Antidiabetic Potential of Mangifera indica Leaf in Streptozotocin-Induced Type 2 Diabetic Rats: Focus on Glycemic Control and Cholesterol Regulation

  • Joyeeta T. Khan,
  • Anika E. Richi,
  • Sanjida A. Riju,
  • Tanjila Jalal,
  • Rejwana J. Orchi,
  • Smita Singh,
  • Phulgen Bhagat,
  • Yasser H. A. Abdel-Wahab and
  • Prawej Ansari

8 April 2024

Mangifera indica (Anacardiaceae family) is renowned for its diverse pharmacological properties, encompassing antidiabetic, antioxidant, and anti-inflammatory effects. The present study delves into the insulin-releasing and glucose-lowering potential...

  • Article
  • Open Access
1 Citations
2,161 Views
13 Pages

Secondary Cardiovascular Disease Prevention Deficit Persists over the Years: A Multicenter Cross-Sectional Study Involving 1003 Consecutive Patients from Greece

  • Rodis D. Paparodis,
  • Ioannis Androulakis,
  • Dimitrios Askitis,
  • Ilias Perogamvros,
  • Nicholaos Angelopoulos,
  • Andreas Rizoulis,
  • Sarantis Livadas and
  • Anastasios Boniakos

27 March 2024

Purpose: Lipid lowering treatments (LLTs) can reduce the risk of atherosclerotic cardiovascular disease (ASCVD). Despite the availability of potent LLTs, our clinical observations suggest an inadequate use of such agents. To evaluate this treatment d...

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Endocrines - ISSN 2673-396X