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Endocrines, Volume 5, Issue 3

2024 September - 16 articles

Cover Story: The adrenal gland is composed of the steroid hormone-secreting cortex and the catecholamine-secreting medulla. Various benign and malignant tumors originate from its distinct layers, among them the highly malignant adrenocortical carcinoma (ACC), arising from the secretory cells of the adrenal cortex, and pheochromocytoma (PCC), originating from the chromaffin cells of the adrenal medulla. ACCs are often diagnosed at advanced and metastatic stages, while PCCs are mostly benign with a malignancy rate of around 10%, strongly dependent on genetic/molecular characteristics. In recent years, novel preclinical murine and human cell line models have been established that better reflect the complexities of both tumor entities. View this paper
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Articles (16)

  • Article
  • Open Access
2,181 Views
11 Pages

Application of Ultrasonography in Stratifying Malignancy Risk for Indeterminate Thyroid Nodules as per TBSRTC 2023

  • Sofia Guerreiro,
  • Mariana Mourão,
  • Isabel Loureiro,
  • Rosário Eusébio,
  • Sule Canberk and
  • Hugo Pinto Marques

20 September 2024

Introduction: Thyroid nodules are extremely common and require complex management to prevent unnecessary surgical intervention and ensure that no malignant disease is overlooked. Several diagnostic tools and scoring systems are available to evaluate...

  • Review
  • Open Access
9 Citations
9,118 Views
24 Pages

Thyroid under Attack: The Adverse Impact of Plasticizers, Pesticides, and PFASs on Thyroid Function

  • Vinicius Gonçalves Rodrigues,
  • Guilherme Henrique,
  • Érica Kássia Sousa-Vidal,
  • Rafaela Martins Miguel de Souza,
  • Evelyn Franciny Cardoso Tavares,
  • Nathana Mezzalira,
  • Thacila de Oliveira Marques,
  • Bruna Monteiro Alves,
  • João Anthony Araújo Pinto and
  • Caroline Serrano-Nascimento
  • + 5 authors

19 September 2024

Endocrine-disrupting chemicals (EDCs) are synthetic or natural compounds that interfere with the endocrine system, inducing harmful effects on organisms depending on the dose and period of exposure. Numerous studies have identified concerning amounts...

  • Article
  • Open Access
7,090 Views
12 Pages

The Predictive Value of the Triglycerides/HDL-Cholesterol Ratio for Diabetes Incidence

  • Bianca de Almeida-Pititto,
  • Julia Ines Branda,
  • Julia M. de Oliveira,
  • Patrícia M. Dualib,
  • Luisa Bittencourt de Aquino Fernandes Dias,
  • Isabela M. Bensenor,
  • Paulo A. Lotufo and
  • Sandra Roberta G. Ferreira

10 September 2024

Background: Type 2 diabetes mellitus (DM) is an important disease with an impact on public health globally. Early assessment is necessary with accessible markers, such as the TG/HDL ratio, in predicting DM. Methods: A total of 11,653 subjects from th...

  • Article
  • Open Access
3,559 Views
10 Pages

How Different Treatments for Acromegaly Modulate Sleep Quality: A Psychometric Study

  • Gaspare Alfì,
  • Danilo Menicucci,
  • Dalì Antonia Ciampa,
  • Vito Di Giura,
  • Giulia Marconcini,
  • Claudio Urbani,
  • Fausto Bogazzi and
  • Angelo Gemignani

6 September 2024

Acromegaly is a rare endocrine syndrome characterized by unrestrained growth hormone (GH) secretion from a GH-secreting pituitary neuroendocrine tumor (PitNET). Data on sleep disorders are scanty and mainly linked to Obstructive Sleep Apnea Syndrome...

  • Review
  • Open Access
1 Citations
3,538 Views
13 Pages

4 September 2024

Background: The prevalence of type 2 diabetes mellitus (T2DM) has been steadily increasing over the past few decades, largely due to the rise in obesity rates. Bariatric surgery is a gastrointestinal surgical treatment focused on achieving weight los...

  • Systematic Review
  • Open Access
9 Citations
4,940 Views
14 Pages

Adiponectin and Leptin during Pregnancy: A Systematic Review of Their Association with Pregnancy Disorders, Fetal Growth and Placental Function

  • Taylor Downs,
  • Fabricio da Silva Costa,
  • Cristiane de Freitas Paganoti,
  • Olivia J. Holland and
  • Deanne H. Hryciw

2 September 2024

During pregnancy, the adipokines leptin and adiponectin can affect placental nutrient transport and inflammatory pathways, potentially leading to altered fetal growth and pregnancy complications including gestational diabetes mellitus (GDM) and preec...

  • Review
  • Open Access
8 Citations
52,541 Views
16 Pages

Synthetic Endocrine Disruptors in Fragranced Products

  • Sawyer Ashcroft,
  • Noura S. Dosoky,
  • William N. Setzer and
  • Prabodh Satyal

15 August 2024

Endocrine disruptors are molecules that can interfere with the proper functioning of the endocrine system and lead to harmful effects in living organisms. This review focuses on the impact of synthetic fragrances, which are commonly found in personal...

  • Article
  • Open Access
1 Citations
9,916 Views
12 Pages

15 August 2024

Dysmenorrhea treatment with 0.5 mg dienogest tablets twice daily (1 mg/day) has proven useful, but its effect on premenstrual disorders has not yet been evaluated. This study aimed to evaluate the efficacy of 0.5 mg dienogest tablets in relieving pre...

  • Review
  • Open Access
2 Citations
6,745 Views
13 Pages

Isolated Growth Hormone Deficiency

  • Anastasia Ibba,
  • Chiara Guzzetti,
  • Lavinia Sanfilippo and
  • Sandro Loche

8 August 2024

Growth hormone deficiency (GHD) is the most frequent pituitary hormone deficiency in childhood, with an incidence of 1 in 4000–10,000 live births. GHD can be congenital (genetic or due to hypothalamic/pituitary abnormalities) or acquired and can be i...

  • Case Report
  • Open Access
2,624 Views
7 Pages

Adult-Onset Case of Female Idiopathic Hypogonadotropic Hypogonadism and Ataxia: Genetic Background

  • Paola Chiarello,
  • Giuseppe Seminara,
  • Sabrina Bossio,
  • Valentina Rocca,
  • Emma Colao,
  • Rodolfo Iuliano and
  • Antonio Aversa

5 August 2024

Adult-onset cases of idiopathic hypogonadotropic hypogonadism (IHH) are characterized by partial or normal puberty development until adolescence and by the impairment of the hypothalamic–pituitary–gonadal (HPG) axis in adulthood. WDR11 an...

  • Review
  • Open Access
3 Citations
8,014 Views
11 Pages

Glucagon-like Peptide-1 Receptor Agonists: Are They as Good as They Seem? A Systematic Review of Severe Adverse Effects

  • Pranjal Sharma,
  • Venkata Buddhavarapu,
  • Gagandeep Dhillon,
  • Ram Kishun Verma,
  • Ramprakash Devadoss,
  • James Raynor,
  • Ripudaman Munjal,
  • Harpreet Grewal and
  • Rahul Kashyap

1 August 2024

As obesity evolves as a global pandemic, the use of drugs to treat it is booming. The latest among these are Glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Along with their use, the incidence of adverse events has become more common. Although...

  • Article
  • Open Access
1 Citations
6,769 Views
19 Pages

Bitter Phytochemicals Acutely Lower Blood Glucose Levels by Inhibition of Glucose Absorption in the Gut

  • Kimberly Marie Palatini Jackson,
  • Reham Mhawish and
  • Slavko Komarnytsky

25 July 2024

For early hominids, frequent encounters with plant foods necessitated the ability to discern bitter poisons and adjust the activity of the gastrointestinal system in anticipation of carbohydrate-rich meals. Plants bitters were also used historically...

  • Article
  • Open Access
2 Citations
2,931 Views
14 Pages

Differences in Exercise-Linked Biomarkers between Premenopausal and Postmenopausal Middle-Aged Females

  • Anthony J. Giannopoulos,
  • Ahmad Mohammad,
  • Maria I. Retsidou,
  • Jessica A. L. Tucker,
  • Derek P. D. Bornath,
  • Seth F. McCarthy,
  • Rebecca E. K. MacPherson,
  • Tom J. Hazell and
  • Panagiota Klentrou

23 July 2024

While the exercise-induced responses of circulated biomarkers related to inflammation and brain health are well documented in humans, little is known about the effect of menopausal status on these responses. This study compared the responses of infla...

  • Article
  • Open Access
2,604 Views
13 Pages

Beverage Consumption Patterns and Their Association with Metabolic Health in Adults from Families at High Risk for Type 2 Diabetes in Europe—The Feel4Diabetes Study

  • Paris Kantaras,
  • Niki Mourouti,
  • Theodora Mouratidou,
  • Ekaterini Chatzaki,
  • Makrina Karaglani,
  • Violeta Iotova,
  • Natalya Usheva,
  • Imre Rurik,
  • Péter Torzsa and
  • Yannis Manios
  • + 3 authors

22 July 2024

In total, 3274 adults (65.2% females) from six European countries were included in this cross-sectional analysis using data from the baseline assessment of the Feel4Diabetes study. Anthropometric, sociodemographic, dietary and behavioral data were as...

  • Feature Paper
  • Review
  • Open Access
3 Citations
4,313 Views
16 Pages

Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma

  • Edlira Luca,
  • Andrea Abate,
  • Katharina Wang,
  • Stefan Bornstein,
  • Sandra Sigala,
  • Felix Beuschlein,
  • Svenja Nölting and
  • Constanze Hantel

5 July 2024

Adrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are often detected at advanced stages and are associated with poor prognosis. PCCs a...

  • Article
  • Open Access
3 Citations
5,260 Views
9 Pages

Androgenic Steroid Hormones and Endurance Exercise in Athletic Women

  • Anthony C. Hackney,
  • Raul Cosme Ramos Prado and
  • Eimear Dolan

2 July 2024

This study investigated the impact of intensive endurance exercise on circulating androgenic steroid hormones in women. Fifteen normally menstruating athletic women participated. They completed intensive endurance exercise (treadmill running) until v...

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Endocrines - ISSN 2673-396X