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Transplantology, Volume 5, Issue 3

2024 September - 11 articles

Cover Story: Vascularized composite allotransplantation has achieved superior outcomes compared to standard reconstructive surgical techniques. However, the long-term use of immunosuppressive medications necessary to control rejection results in significant post-transplant morbidity and mortality. Despite prolonged immunotherapy, donor-specific antibodies often develop, leading to chronic rejection and delayed graft failure. Thus, developing safe and effective tolerance strategies is crucial. This review examines recent findings on alloantibody-mediated rejection in clinical VCAs and emphasizes the need for tolerance-inducing approaches that could significantly enhance graft outcomes and patient quality of life. View this paper
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Articles (11)

  • Review
  • Open Access
2 Citations
3,975 Views
10 Pages

Sodium glucose cotransporter type 2 inhibitors are a new class of drugs that act on the cardiovascular system, kidneys and metabolism in a multiple ways. Indeed, even though their principal action involves the transport of sodium and glucose in the c...

  • Brief Report
  • Open Access
1 Citations
2,023 Views
8 Pages

Background: Healthcare outcomes are influenced by both the effectiveness of healthcare delivery and the health literacy of patients. Patient education materials (PEMs) play a crucial role in disseminating health information to the patients. PEMs need...

  • Article
  • Open Access
2,751 Views
8 Pages

Organ Donation through the Eyes of Jordanian Medical Students

  • Saif Yamin,
  • Hamzeh Feras Alshahwan,
  • Jehad Feras AlSamhori,
  • Osama Alfreahat,
  • Abdallah Alhalbouni and
  • Zaid Alwarawrah

Background: Organ donation is a critical component in the field of transplantation medicine, offering lifesaving opportunities for patients with end-stage organ failure. This study investigated the knowledge, attitude, and practice (KAP) survey regar...

  • Article
  • Open Access
2 Citations
2,819 Views
15 Pages

Background: Corneal transplantation faces significant challenges due to the shortage in donor corneas. Porcine corneas have emerged as a potential solution due to their similarities in biomechanical properties with pigs, yet xenoimmune rejection pose...

  • Brief Report
  • Open Access
2 Citations
2,404 Views
7 Pages

Combined Heart-Liver Transplant vs. Heart Transplant Alone: A Single Center Experience

  • Ritika Mazumder,
  • Andrew Ford,
  • Omar T. Sims and
  • Jamak Modaresi Esfeh

Combined heart-liver transplantation (CHLT) is a viable option for concurrent heart and liver failure, yet its indications are unclear. This preliminary study aimed to describe pre-transplant characteristics and outcomes of patients with liver fibros...

  • Article
  • Open Access
1 Citations
2,199 Views
12 Pages

Dual and Pediatric En-Bloc Compared to Living Donor Kidney Transplant: A Single Center Retrospective Review

  • Todd J. Robinson,
  • Thierry Schöb,
  • Paola A. Vargas,
  • Caroline Schöb,
  • Alp Demirag and
  • Jose Oberholzer

Safely expanding the use of extended-criteria organ donors is critical to increase access to kidney transplantation and reduce wait list mortality. We performed a retrospective analysis of 24 pediatric en-bloc (PEB) compared to 13 dual-kidney transpl...

  • Review
  • Open Access
3,504 Views
11 Pages

High-Resource Users among Renal Transplant Recipients

  • Aleksandra Maciejczyk,
  • Anna Łabuś and
  • Mariusz Niemczyk

Chronic kidney disease (CKD) represents a significant global epidemiological challenge, demanding considerable financial resources for treatment. Renal transplantation is the optimal approach for end-stage renal failure, being the most cost-effective...

  • Perspective
  • Open Access
1 Citations
2,297 Views
15 Pages

The Impact of Alloantibodies on Clinical VCA Outcomes and the Need for Immune Tolerance

  • Caitlin M. Blades,
  • Nalu Navarro-Alvarez,
  • Christene A. Huang and
  • David W. Mathes

The functional outcomes and restoration of form after vascularized composite allotransplantation (VCA) have exceeded the results that could be achieved with current autologous surgical techniques. However, the longevity of VCA grafts has been limited...

  • Brief Report
  • Open Access
2,302 Views
8 Pages

Many patients with a hematologic malignancy have other pre-existing conditions at the time of consideration of an allogeneic stem cell transplant (allo-HSCT). Among these, mild-to-moderate chronic kidney disease (CKD) is a common comorbid condition t...

  • Review
  • Open Access
1 Citations
4,222 Views
11 Pages

Bacterial Infections in End-Stage Liver Disease: Implications for Liver Transplantation

  • Alberto Ferrarese,
  • Marco Senzolo,
  • Anna Maria Cattelan,
  • Lolita Sasset,
  • Sara Battistella,
  • Alberto Zanetto,
  • Giacomo Germani,
  • Francesco Paolo Russo,
  • Martina Gambato and
  • Patrizia Burra
  • + 4 authors

Bacterial infections are a common complication in patients with decompensated liver cirrhosis. The complex landscape of cirrhosis, characterized by immune paralysis and an exhausted response to exogenous triggers, explains the higher prevalence of su...

  • Review
  • Open Access
2 Citations
4,590 Views
13 Pages

Evolving Biomarkers in Kidney Transplantation

  • Maurizio Salvadori,
  • Alberto Rosati and
  • Giuseppina Rosso

Precision medicine is mainly based on reliable and noninvasive biomarkers. The aim of this review was to describe the newest biomarkers in the field of kidney transplantation and kidney rejection, one of the most common and severe complications. The...

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Transplantology - ISSN 2673-3943