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Hearts, Volume 6, Issue 3

September 2025 - 9 articles

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Articles (9)

  • Article
  • Open Access
2,954 Views
13 Pages

Myocardial Work’s Impact in the Evaluation of Advanced Heart Failure

  • Luca Martini,
  • Antonio Pagliaro,
  • Hatem Soliman Aboumarie,
  • Massimo Maccherini,
  • Serafina Valente,
  • Giulia Elena Mandoli,
  • Michael Y. Henein and
  • Matteo Cameli

3 September 2025

Background: Left ventricular myocardial work (MW) derived from non-invasive pressure–strain loops has emerged as a load-adjusted index of contractile performance. Its value for risk stratification in advanced heart failure (HF) remains uncertai...

  • Article
  • Open Access
1,823 Views
8 Pages

Anxiety and Depression Symptoms in Children and Adolescents with Congenital Heart Disease

  • Isabel Uphoff,
  • Charlotte Schöneburg,
  • Renate Oberhoffer-Fritz,
  • Peter Ewert and
  • Jan Müller

15 August 2025

Background: Congenital heart disease (CHD) is associated with an increased risk of anxiety and depression in adults. However, little is known about the mental health of children and adolescents with CHD. The aim of this study was to assess difference...

  • Systematic Review
  • Open Access
3,228 Views
16 Pages

Systematic Review and Meta-Analysis of Cardiac MRI T1 and ECV Measurements in Pre-Heart Failure Populations

  • Robert S. Doyle,
  • Ross Walsh,
  • Jamie Walsh,
  • Hugo C. Temperley,
  • John McCormick and
  • Gerard Giblin

13 August 2025

Background/Objectives: Heart failure (HF) often develops from a prolonged asymptomatic phase where early detection could prevent progression. Pre-heart failure (pre-HF) populations—those with risk factors (Stage A) or subclinical myocardial cha...

  • Systematic Review
  • Open Access
1 Citations
3,845 Views
16 Pages

Machine Learning Application in Different Imaging Modalities for Detection of Obstructive Coronary Artery Disease and Outcome Prediction: A Systematic Review and Meta-Analysis

  • Peter McGranaghan,
  • Doreen Schoeppenthau,
  • Antonia Popp,
  • Anshul Saxena,
  • Sharat Kothakapu,
  • Muni Rubens,
  • Gabriel Jiménez,
  • Pablo Gordillo,
  • Emir Veledar and
  • Alaa Abd El Al
  • + 3 authors

7 August 2025

Background/Objectives: Invasive coronary angiography (ICA) is the gold standard for the diagnosis of coronary artery disease (CAD), with various non-invasive imaging modalities also available. Machine learning (ML) methods are increasingly applied to...

  • Article
  • Open Access
1,218 Views
10 Pages

6 August 2025

Background/Objectives: While elevated Lp(a) levels are associated with incident heart failure development, the role of Lp(a) in established heart failure with reduced ejection fraction (HFrEF) versus heart failure with preserved ejection fraction (HF...

  • Article
  • Open Access
4,788 Views
14 Pages

Evaluating Large Language Models in Cardiology: A Comparative Study of ChatGPT, Claude, and Gemini

  • Michele Danilo Pierri,
  • Michele Galeazzi,
  • Simone D’Alessio,
  • Melissa Dottori,
  • Irene Capodaglio,
  • Christian Corinaldesi,
  • Marco Marini and
  • Marco Di Eusanio

19 July 2025

Background: Large Language Models (LLMs) such as ChatGPT, Claude, and Gemini are being increasingly adopted in medicine; however, their reliability in cardiology remains underexplored. Purpose of the study: To compare the performance of three general...

  • Review
  • Open Access
7,452 Views
14 Pages

17 July 2025

Hypertensive left ventricular hypertrophy (LVH) is an ominous cardiovascular sequel to chronic hypertension, marked by structural and functional alterations in the heart. Identified as a significant risk factor for adverse cardiovascular outcomes, LV...

  • Review
  • Open Access
2 Citations
5,548 Views
18 Pages

A Contemporary Review of Clinical Manifestations, Evaluation, and Management of Cardiac Complications of Iron Overload

  • Ankit Agrawal,
  • Joseph El Dahdah,
  • Elio Haroun,
  • Aro Daniela Arockiam,
  • Ahmad Safdar,
  • Sharmeen Sorathia,
  • Tiffany Dong,
  • Brian Griffin and
  • Tom Kai Ming Wang

3 July 2025

Cardiac iron overload is a rare but important adverse consequence of systemic iron overload, marked by the abnormal accumulation of iron in the myocardium. It is most typically caused by hereditary hemochromatosis (mutations in the HFE gene) or secon...

  • Article
  • Open Access
1,490 Views
9 Pages

Use of Cangrelor in Patients Undergoing Percutaneous Coronary Intervention: Insights and Outcomes from District General Hospital

  • Ibrahim Antoun,
  • Sotirios Dardas,
  • Falik Sher,
  • Mueed Akram,
  • Navid Munir,
  • Georgia R. Layton,
  • Mustafa Zakkar,
  • Kamal Chitkara,
  • Riyaz Somani and
  • Andre Ng

22 June 2025

Background/Objectives: Cangrelor, an intravenous P2Y12 inhibitor, is increasingly used during percutaneous coronary intervention (PCI) for rapid and reversible platelet inhibition in patients unable to take oral antiplatelet agents, particularly in e...

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Hearts - ISSN 2673-3846