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Applied Nano, Volume 2, Issue 4

2021 December - 6 articles

Cover Story: Organ-on-a-chip technology has been mainly imaged by optical and fluorescence microscopy. Meanwhile Transmission Electron Microscopy (TEM) remains unexplored in this area. In our work we propose a TEM sample preparation method, that allows to process a microfluidic chip without its prior deconstruction, into TEM-compatible specimens. This approach allowed us to obtain cross-sections of a tumor blood vessel-on-a-chip model with cells cultured inside, and to observe cell adaptation to the channel geometry, as well as the characteristic endothelial cells tight junctions. The proposed sample preparation method facilitates the electron microscopy ultrastructural characterization of biological samples cultured in organ-on-a-chip devices. View this paper
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Articles (6)

  • Article
  • Open Access
3,440 Views
9 Pages

15 December 2021

In the context of a full-potential orbital-free approach for the modeling of multi-atomic systems we investigated the dependence of the cohesive energies and bulk elastic modules of the large nanosystems Cn (n is up to 4096 atoms), Aln (n is up to 23...

  • Feature Paper
  • Article
  • Open Access
9 Citations
7,912 Views
15 Pages

Synthesis, Characterization and Catalytic Activity of UiO-66-NH2 in the Esterification of Levulinic Acid

  • Daiana A. Bravo Fuchineco,
  • Angélica C. Heredia,
  • Sandra M. Mendoza,
  • Enrique Rodríguez-Castellón and
  • Mónica E. Crivello

10 December 2021

The massive use of petroleum and its possible exhaustion are driving the current research trend to study alternative raw materials from biomass for organic reactions. In this context, the present article presents a study of the catalytic esterificati...

  • Article
  • Open Access
4,364 Views
14 Pages

Characterization of Organic Molecules Grafted to Silica or Bismuth Nanoparticles by NMR

  • Céline Henoumont,
  • Gauthier Hallot,
  • Estelle Lipani,
  • Catherine Gomez,
  • Robert N. Muller,
  • Luce Vander Elst,
  • Marc Port and
  • Sophie Laurent

4 November 2021

NMR is a powerful characterization tool and we propose to study the surface of silica or bismuth nanoparticles dedicated to medical applications in order to evidence the covalent grafting of organic molecules on their surface. For that aim, DOSY expe...

  • Article
  • Open Access
1 Citations
4,453 Views
11 Pages

Low-Cost Nanostructured Thin Films as Covert Laser Readable Security Tags for Large-Scale Productions Tracking

  • Laurent Gravier,
  • Yves Salvadé,
  • Damien Pidoux,
  • Julien Maritz and
  • Marco Laratta

29 October 2021

We report here the feasibility study of anti-counterfeiting low-cost nanostructured flexible security tags for the tracking of large-scale fabrication products, such as pharmaceuticals or original equipment manufacturers. The fabrication process make...

  • Article
  • Open Access
7 Citations
4,395 Views
16 Pages

17 October 2021

Nitrogen doping in carbon materials can modify the employed carbon material’s electronic and structural properties, which helps in creating a stronger metal-support interaction. In this study, the role of nitrogen doping in improving the durability o...

  • Article
  • Open Access
3 Citations
5,645 Views
14 Pages

Towards Cellular Ultrastructural Characterization in Organ-on-a-Chip by Transmission Electron Microscopy

  • Adrianna Glinkowska Mares,
  • Natalia Feiner-Gracia,
  • Yolanda Muela,
  • Gema Martínez,
  • Lidia Delgado,
  • Lorenzo Albertazzi and
  • Silvia Pujals

30 September 2021

Organ-on-a-chip technology is a 3D cell culture breakthrough of the last decade. This rapidly developing field of bioengineering intertwined with microfluidics provides new insights into disease development and preclinical drug screening. So far, opt...

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Appl. Nano - ISSN 2673-3501