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Gastrointestinal Disorders, Volume 4, Issue 3

2022 September - 10 articles

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Articles (10)

  • Article
  • Open Access
6 Citations
9,845 Views
9 Pages

Background: Capecitabine and oxaliplatin (CAPOX) and infusional 5-fluouracil, folinic acid, and oxaliplatin (FOLFOX) are the two chemotherapy regimens in current clinical use for the adjuvant treatment of colorectal cancer (CRC). Many centers in Newf...

  • Article
  • Open Access
5 Citations
4,855 Views
9 Pages

Evaluation of Accuracy and Feasibility of a New-Generation Ultra-Rapid Urease Test for Detection of Helicobacter pylori Infection

  • Marco Cagnoni,
  • Cristiano Pagnini,
  • Marco Crovaro,
  • Antonio Aucello and ,
  • Riccardo Urgesi,
  • Lorella Pallotta,
  • Gianfranco Fanello,
  • Maria Carla Di Paolo and
  • Maria Giovanna Graziani
  • + 4 authors+ 0 author

Helicobacter pylori (Hp) infection can be diagnosed by invasive and noninvasive methods, and, among the former, Rapid Urease Tests (RUTs) are an important option. Accuracy and rapidity of results are fundamental for RUTs. The aim of the study is to p...

  • Article
  • Open Access
3 Citations
3,769 Views
15 Pages

Identification of a Five-MiRNA Expression Assay to Aid Colorectal Cancer Diagnosis

  • Matthew G. Davey,
  • Gerard Feeney,
  • Heidi Annuk,
  • Maxwell Paganga and ,
  • Emma Holian,
  • Aoife J. Lowery,
  • Michael J. Kerin and
  • Nicola Miller
  • + 3 authors+ 0 author

Introduction: One-third of colorectal cancer (CRC) patients present with advanced disease, and establishing control remains a challenge. Identifying novel biomarkers to facilitate earlier diagnosis is imperative in enhancing oncological outcomes. We...

  • Article
  • Open Access
2 Citations
5,199 Views
10 Pages

Fecal Calprotectin, Chitinase 3-Like-1, S100A12 and Osteoprotegerin as Markers of Disease Activity in Children with Crohn’s Disease

  • Adriaan G. Volkers,
  • Laura Appleton,
  • Richard B. Gearry,
  • Christopher M. Frampton and ,
  • Floris A. E. de Voogd,
  • Annemieke M. Peters van Ton,
  • Steven T. Leach,
  • Daniel A. Lemberg and
  • Andrew S. Day
  • + 4 authors+ 0 author

Fecal calprotectin (FC), chitinase 3-like-1 protein (CHI3L1), S100A12 and osteoprotegerin (OPG) are biomarkers of intestinal inflammation. This cross-sectional study aimed to evaluate these biomarkers in a cohort of children with Crohn’s diseas...

(This article belongs to the Special Issue Aspects of the Pathogenesis and Management of the Inflammatory Bowel Diseases 2.0)
  • Article
  • Open Access
7 Citations
6,629 Views
15 Pages

Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer

  • Vincent Ho,
  • Liping Chung,
  • Stephanie H. Lim,
  • Yafeng Ma and ,
  • Bin Wang,
  • Vivienne Lea,
  • Askar Abubakar,
  • Weng Ng,
  • Mark Lee and
  • C. Soon Lee
  • + 7 authors+ 2 authors

The DNA damage response (DDR) is critical for maintaining genome stability, and abnormal DDR—resulting from mutations in DNA damage-sensing and repair proteins—is a hallmark of cancer. Here, we aimed to investigate the predictive power of...

  • Article
  • Open Access
2 Citations
4,264 Views
12 Pages

Shear-Wave Elastography Using Commercially Available Ultrasound in a Mouse Model of Chronic Liver Disease

  • Yoko Futani,
  • Megumi Hamano,
  • Riku Matsumoto,
  • Saya Hashimoto and ,
  • Rikuto Nishimura,
  • Mika Ueda,
  • Narumi Arihara,
  • Hideki Fujii,
  • Masafumi Ono and
  • Yoshihiro Kamada
  • + 7 authors+ 2 authors

Elastography is currently used clinically to diagnose the degree of liver stiffness. We sought to develop a shear-wave elastography (SWE) measurement method using ultrasound in mice and to compare its results with those of other noninvasive tests for...

  • Article
  • Open Access
3,013 Views
12 Pages

Low Baseline Plasma L-Glutamine Concentration Identifies Hepatocellular Carcinoma Patients at High Risk of Developing Early Gastrointestinal Adverse Events during Sorafenib Treatment

  • Loreto Boix,
  • Víctor Sapena,
  • Esther Samper,
  • Álvaro Díaz-González and ,
  • Neus Llarch,
  • Gemma Iserte,
  • Leonardo G. Da Fonseca,
  • Marco Sanduzzi-Zamparelli,
  • Alejandro Forner and
  • María Reig
  • + 6 authors+ 1 author

Gastrointestinal adverse events (GIAEs) are common in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Diarrhea is a prevalent event responsible for treatment interruptions and dosage modifications. Our study evaluates th...

  • Article
  • Open Access
4 Citations
3,117 Views
12 Pages

Background: During the COVID-19 pandemic, the Flemish colorectal cancer (CRC) screening program (by fecal immunochemical test, FIT) was suspended and non-urgent medical procedures were discommended. This study estimates how this impacted diagnostic c...

  • Review
  • Open Access
3 Citations
3,895 Views
21 Pages

The purpose of this article is to provide a direction for translational research based on an analysis of the nature of complex, immune-related conditions such as obesity and coeliac disease. In essence, it seems that the prevalence of these non-commu...

  • Article
  • Open Access
7 Citations
5,207 Views
11 Pages

Colorectal cancer screening can contribute to reducing colorectal cancer incidence and mortality. Findings on disparities in the utilization of colorectal cancer screening between migrants and non-migrants have been inconsistent, with some studies re...

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Gastrointest. Disord. - ISSN 2624-5647