Review Reports

Round 1

Reviewer 1 Report

This is a very good, comprehensive review and I suggest only a couple of minor changes: 

1. Page 245 word "screws" is mentioned twice
2. Spinal fusion surgery complications. When pseudoarthrosis is mentioned please mention also "transfer lesion" also as a postsurgical complication
3. Lines 405-406 please revise the sentence
4. Figure 10. The case is very educational but hard to follow the explanations since on planar images a large arrow is on the left ankle and the SPECT images discuss the findings on the right. I think an arrowhead on the right ankle too is needed on the planar image same color as in SPECT.   
5. Citation 102 ( before mentioning Figure 12 ) is probably incorrect since the article is discussing the AGA scintigraphy.
6. Line 494 although correct, the phrasing is is confusing since sulfur-colloid is mentioned after Ga-67.

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

This is a nice and well-written paper.

Figures are really nice and instructive.

I suggested some improvements:
- Fig.1 This is a monolateral spondylolysis, classically involving the isthmic part of the posterior arch of L5 vertebra. Specify-correct this in figure legend and moreover you should link this figure in the section "EVALUATION OF PAIN OF SPINAL ORIGIN"

- In your experience, may SPECT/CT have a role in the differential diagnosis between osteoporotic and neoplastic atraumatic vertebral fractures? Please, discuss briefly this point and add some data if you feel it pertinent and relevant.

- Please, in 'Introduction' section add some basic elements of SPECT study how it works from a physical point of view, to introduce and present the following section of the papers.

 

Author Response

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Author Response File: Author Response.pdf