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Long Non-Coding RNAs in Multiple Myeloma
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Circulating microRNAs and Their Role in Multiple Myeloma

1
Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
2
CREA Laboratory, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
3
Department of Hematology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
4
Department of Molecular and Translational Medicine, University of Brescia Medical School, 25123 Brescia, Italy
5
Clinical Chemistry Laboratory, Department of Diagnostics, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
6
Laboratory for Stem Cells Manipulation and Cryopreservation, Department of Transfusion Medicine, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
7
Clinical and Translational Medicine, Clínica Universidad de Navarra, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2019, 5(2), 37; https://doi.org/10.3390/ncrna5020037
Received: 13 March 2019 / Revised: 26 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Non-Coding RNA in Multiple Myeloma)
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Abstract

Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also highlighted the importance of the functional cross-talk between the tumor clone and the surrounding bone marrow milieu, as a relevant player of MM pathogenesis. These findings have certainly enhanced our understanding of the underlying mechanisms supporting MM pathogenesis and disease progression. Within the specific field of small non-coding RNA-research, recent studies have provided evidence for considering microRNAs as a crucial regulator of MM biology and, in this context, circulating microRNAs have been shown to potentially contribute to prognostic stratification of MM patients. The present review will summarize the most recent studies within the specific topic of microRNAs and circulating microRNAs in MM. View Full-Text
Keywords: multiple myeloma; plasma Cell dyscrasia; miRNAs; circulating miRNAs; circulating exosomal-miRNAs multiple myeloma; plasma Cell dyscrasia; miRNAs; circulating miRNAs; circulating exosomal-miRNAs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Federico, C.; Sacco, A.; Belotti, A.; Ribolla, R.; Cancelli, V.; Giacomini, A.; Ronca, R.; Chiarini, M.; Imberti, L.; Marini, M.; Rossi, G.; Presta, M.; Paiva, B.; Roccaro, A.M. Circulating microRNAs and Their Role in Multiple Myeloma. Non-Coding RNA 2019, 5, 37.

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