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Non-Coding RNA, Volume 10, Issue 5

2024 October - 7 articles

Cover Story: Lung cancer remains a leading cause of cancer-related deaths worldwide, largely due to late-stage diagnoses and aggressive disease progression. Despite advancements, the prognosis for lung cancer patients remains poor. Emerging research highlights non-coding RNAs (ncRNAs)—including microRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)—as key regulators of gene expression, influencing tumor development, progression, metastasis, and treatment resistance. This review explores the potential of ncRNAs as biomarkers for early diagnoses, prognoses, and predictions of therapeutic responses in lung cancer. Advances in ncRNA-based therapies offer promising avenues for personalized treatment, although challenges like delivery and large-scale validation remain. View this paper
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Articles (7)

  • Review
  • Open Access
27 Citations
8,730 Views
8 Pages

MicroRNA Biogenesis, Gene Regulation Mechanisms, and Availability in Foods

  • Amilton S. de Mello,
  • Bradley S. Ferguson,
  • Erica L. Shebs-Maurine and
  • Francine M. Giotto

11 October 2024

MicroRNAs (miRNAs) are small, non-coding RNAs that control gene expression by degrading or repressing mRNA translation into proteins. Research recently suggested that food-derived miRNAs are bioavailable and may be absorbed in the gastrointestinal tr...

(This article belongs to the Section Small Non-Coding RNA)
  • Review
  • Open Access
5 Citations
2,791 Views
24 Pages

30 September 2024

Epithelial ovarian cancer (EOC) with its high death incidence rate is generally detected at advanced stages. During its progression, EOC often develops peritoneal metastasis aggravating the outcomes of EOC patients. Studies on non-coding RNAs (ncRNAs...

  • Review
  • Open Access
  • Best Paper Award
20 Citations
4,909 Views
25 Pages

Non-Coding RNA as a Biomarker in Lung Cancer

  • Chahat Suri,
  • Shashikant Swarnkar,
  • LVKS Bhaskar and
  • Henu Kumar Verma

30 September 2024

Introduction: Lung cancer remains one of the most prevalent and deadly cancers globally, with high mortality rates largely due to late-stage diagnosis, aggressive progression, and frequent recurrence. Despite advancements in diagnostic techniques and...

(This article belongs to the Special Issue Non-coding RNA as Biomarker in Cancer)
  • Review
  • Open Access
16 Citations
5,180 Views
20 Pages

Back to the Origin: Mechanisms of circRNA-Directed Regulation of Host Genes in Human Disease

  • Haomiao Yuan,
  • Xizhou Liao,
  • Ding Hu,
  • Dawei Guan and
  • Meihui Tian

24 September 2024

Circular RNAs (circRNAs) have been shown to be pivotal regulators in various human diseases by participating in gene splicing, acting as microRNA (miRNA) sponges, interacting with RNA-binding proteins (RBPs), and translating into short peptides. As t...

(This article belongs to the Section Small Non-Coding RNA)
  • Article
  • Open Access
13 Citations
4,831 Views
16 Pages

2 September 2024

Following the acute phase of SARS-CoV-2 infection, certain individuals experience persistent symptoms referred to as long COVID. This study analyzed the patients categorized into three distinct groups: (1) individuals presenting rheumatological sympt...

(This article belongs to the Collection Non-Coding RNAs, COVID-19, and Long-COVID)
  • Article
  • Open Access
10 Citations
4,070 Views
14 Pages

The Circulating miR-107 as a Potential Biomarker Up-Regulated in Castration-Resistant Prostate Cancer

  • Jonathan Puente-Rivera,
  • David Alejandro De la Rosa Pérez,
  • Stephanie I. Nuñez Olvera,
  • Elisa Elvira Figueroa-Angulo and ,
  • José Gadú Campos Saucedo,
  • Omar Hernández-León and
  • María Elizbeth Alvarez-Sánchez
  • + 2 authors+ 0 author

Prostate cancer (PCa) is a prevalent malignancy in men globally. Current diagnostic methods like PSA testing have limitations, leading to overdiagnosis and unnecessary treatment. Castration-resistant prostate cancer (CRPC) emerges in some patients re...

(This article belongs to the Section Detection and Biomarkers of Non-Coding RNA)
  • Article
  • Open Access
3 Citations
4,004 Views
19 Pages

MicroRNA Profiling as a Predictive Indicator for Time to First Treatment in Chronic Lymphocytic Leukemia: Insights from the O-CLL1 Prospective Study

  • Ennio Nano,
  • Francesco Reggiani,
  • Adriana Agnese Amaro,
  • Paola Monti and ,
  • Monica Colombo,
  • Nadia Bertola,
  • Fabiana Ferrero,
  • Franco Fais,
  • Antonella Bruzzese and
  • Giovanna Cutrona
  • + 19 authors+ 14 authors

A “watch and wait” strategy, delaying treatment until active disease manifests, is adopted for most CLL cases; however, prognostic models incorporating biomarkers have shown to be useful to predict treatment requirement. In our prospectiv...

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Non-Coding RNA - ISSN 2311-553X