Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation

Geng, Xiong; Tian, Weina; Zhuang, Miaomiao; Shang, Huayan; Gong, Ziyi; Li, Jianrong

doi:10.3390/foods13244113

Open AccessArticle

Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation

by

Xiong Geng

,

Weina Tian

,

Miaomiao Zhuang

,

Huayan Shang

,

Ziyi Gong

and

Jianrong Li

^*

Department of Food Science and Engineering, College of Food Science and Engineering, Bohai University, Jinzhou 121013, China

^*

Author to whom correspondence should be addressed.

Foods 2024, 13(24), 4113; https://doi.org/10.3390/foods13244113

Submission received: 22 November 2024 / Revised: 14 December 2024 / Accepted: 17 December 2024 / Published: 19 December 2024

(This article belongs to the Special Issue Bioactive Ingredients in Functional Foods—Their Role in Lipid Metabolism)

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Abstract

The objective of this study was to examine the hypolipidemic effect and potential mechanism of action of green radish polysaccharide (GRP) in hyperlipidemic mice. We found that in mice fed a high-fat diet, supplementing with GRP reduced body weight and liver index, significantly improved serum lipid levels and markers of liver damage, and mitigated oxidative stress and inflammation. Mechanistically, in these hyperlipidemic mice, the size of fat cells was reduced by GRP, and the abnormal accumulation of lipid droplets was reduced. We also found that GRP regulates the composition of the intestinal microbiota, including the ratio of Firmicutes to Mycobacteria F/B and the levels of Blautia spp., which have been shown to alleviate liver damage and treat hyperlipidemia. Metabolite pathway analysis using the Kyoto Encyclopedia of Genes and Genomes identified the glycolysis/glycolytic metabolism and propionate metabolism pathways as potential targets for GRP in the amelioration of hyperlipidemia.

Keywords: green radish; hyperlipidemia; polysaccharides; intestinal flora

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MDPI and ACS Style

Geng, X.; Tian, W.; Zhuang, M.; Shang, H.; Gong, Z.; Li, J. Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation. Foods 2024, 13, 4113. https://doi.org/10.3390/foods13244113

AMA Style

Geng X, Tian W, Zhuang M, Shang H, Gong Z, Li J. Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation. Foods. 2024; 13(24):4113. https://doi.org/10.3390/foods13244113

Chicago/Turabian Style

Geng, Xiong, Weina Tian, Miaomiao Zhuang, Huayan Shang, Ziyi Gong, and Jianrong Li. 2024. "Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation" Foods 13, no. 24: 4113. https://doi.org/10.3390/foods13244113

APA Style

Geng, X., Tian, W., Zhuang, M., Shang, H., Gong, Z., & Li, J. (2024). Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation. Foods, 13(24), 4113. https://doi.org/10.3390/foods13244113

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation

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