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Biomedicines 2017, 5(2), 26;

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer

Stem Cells and Cancer Research Laboratory, CIBERONC. Institut Hospital del Mar Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Veronique Baud
Received: 31 March 2017 / Revised: 15 May 2017 / Accepted: 19 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Roles of NF-κB in Cancer and Their Therapeutic Approaches)
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Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB members in NF-κB unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of IκB kinase complexes (IKKs) and IκBs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development. View Full-Text
Keywords: Cancer; NF-κB; Non-conventional pathways; IKKs; IκBs Cancer; NF-κB; Non-conventional pathways; IKKs; IκBs

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Colomer, C.; Marruecos, L.; Vert, A.; Bigas, A.; Espinosa, L. NF-κB Members Left Home: NF-κB-Independent Roles in Cancer. Biomedicines 2017, 5, 26.

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