Next Article in Journal / Special Issue
NF-κB in Hematological Malignancies
Previous Article in Journal
Implications of a Multi-Step Trigger of Retinal Regeneration in the Adult Newt
Previous Article in Special Issue
Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB
Open AccessFeature PaperReview

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer

Stem Cells and Cancer Research Laboratory, CIBERONC. Institut Hospital del Mar Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Veronique Baud
Biomedicines 2017, 5(2), 26;
Received: 31 March 2017 / Revised: 15 May 2017 / Accepted: 19 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Roles of NF-κB in Cancer and Their Therapeutic Approaches)
Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB members in NF-κB unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of IκB kinase complexes (IKKs) and IκBs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development. View Full-Text
Keywords: Cancer; NF-κB; Non-conventional pathways; IKKs; IκBs Cancer; NF-κB; Non-conventional pathways; IKKs; IκBs
Show Figures

Graphical abstract

MDPI and ACS Style

Colomer, C.; Marruecos, L.; Vert, A.; Bigas, A.; Espinosa, L. NF-κB Members Left Home: NF-κB-Independent Roles in Cancer. Biomedicines 2017, 5, 26.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop