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New Insights into the Pathophysiology and Treatment of Fibromyalgia

Department of Neurology, St. Mauritius Therapieklinik, 40670 Meerbusch, Germany
Department of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany
Department of Psychosomatic Medicine and Psychotherapy, LWL University Hospital, Ruhr-University Bochum, 44791 Bochum, Germany
Author to whom correspondence should be addressed.
Academic Editor: Kim Lawson
Biomedicines 2017, 5(2), 22;
Received: 1 April 2017 / Revised: 2 May 2017 / Accepted: 8 May 2017 / Published: 13 May 2017
(This article belongs to the Special Issue Drug Therapies for the Treatment of Fibromyalgia)
Fibromyalgia is characterized by chronic widespread pain and several additional symptoms such as fatigue, cognitive dysfunction, depressive episodes, and anxiety. The underlying pathophysiology of fibromyalgia is still poorly understood, and treatment is often unsatisfactory. Current research provides evidence for altered pain processing in chronic pain patients, and specifically in fibromyalgia patients, possibly based on altered functional connectivity and brain chemistry in brain regions within the pain processing system. Besides discussing evidence from studies applying brain imaging (specifically resting state fMRI (Functional magnetic resonance imaging)), the current review aims at providing an overview of pharmacological and non-pharmacological treatment options. We will also summarize the most important results from recently performed brain imaging studies providing new insights into the potential mechanisms of various therapeutic approaches. View Full-Text
Keywords: fibromyalgia; chronic pain; resting state; fMRI (functional magnetic resonance imaging); learning fibromyalgia; chronic pain; resting state; fMRI (functional magnetic resonance imaging); learning
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Schmidt-Wilcke, T.; Diers, M. New Insights into the Pathophysiology and Treatment of Fibromyalgia. Biomedicines 2017, 5, 22.

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