Review Reports

Round 1

Reviewer 1 Report

Dear authors 

The manuscript is well-written and interesting in its area of research. I propose to add a table and a graph describing the findings of this study. 

kind regards 

Author Response

I would like to thank the Reviewer for their time in reviewing the manuscript and for their helpful suggestions in improving the manuscript.  I am delighted that you found the manuscript to be interesting.  Per your suggestion I have included two tables in the revised manuscript; one outlining manuscripts published regarding PPFE after HSCT and another summarizing results of biomarker studies in PPFE.  I hope that the Reviewer finds the revised manuscript acceptable for publication.

Reviewer 2 Report

This is a very interesting review on pleuropulmonary elastosis

2 minor comments

1 how to differentiate it from the IPF?

2 a table with the studies reviewed so that the reader had a quicker image on the rarity of the disease and its closer link to stem cell transplantation 

 

Author Response

I would like to thank the Reviewer for their time in reviewing the manuscript and for their helpful suggestions in improving the manuscript.  I am delighted that you found the manuscript to be interesting.  Per your suggestion I have included additional description on how to differentiate IPF and PPFE.  This is a very interesting point and continues to be a challenge at this point.  In addition, I have now included a table outlining manuscripts published regarding PPFE after HSCT to assist the reader in reviewing this topic.  I hope that the Reviewer finds the revised manuscript acceptable for publication.

Reviewer 3 Report

This review discussed what is currently known regarding PPFE as a complication after HSCT highlighting discussions regarding establishing a diagnosis, potential biomarkers, current treatments, and clinical outcomes and prognosis.I think the author gave a detailed introduction to this field.

Author Response

I would like to thank the Reviewer for their time in reviewing the manuscript and for their helpful suggestions in improving the manuscript.  I am delighted that you found the manuscript to be a detailed introduction.  In the revised manuscript,  in response to helpful comments from the Reviewers, I have included two tables; one outlining the manuscripts published regarding PPFE after HSCT and another summarizing results of biomarker studies in PPFE.  I have also expanded the discussions regarding the differentiating IPF from PPFE.  I hope that the Reviewer finds the revised manuscript acceptable for publication.