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Review

Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects

by 1,2,3,*, 2, 1,2 and 1,2,3,*
1
Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia
2
Marlin Biotech LLC, 354340 Sochi, Russia
3
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Academic Editor: Ilayaraja Muthuramu
Biomedicines 2022, 10(5), 1140; https://doi.org/10.3390/biomedicines10051140
Received: 30 April 2022 / Revised: 13 May 2022 / Accepted: 13 May 2022 / Published: 15 May 2022
(This article belongs to the Special Issue Adeno-Associated Virus Vectors for Gene Therapy)
Adeno-associated virus (AAV) vectors have become an attractive tool for efficient gene transfer into animal tissues. Extensively studied as the vehicles for therapeutic constructs in gene therapy, AAVs are also applied for creating animal models of human genetic disorders. Neurological disorders are challenging to model in laboratory animals by transgenesis or genome editing, at least partially due to the embryonic lethality and the timing of the disease onset. Therefore, gene transfer with AAV vectors provides a more flexible option for simulating genetic neurological disorders. Indeed, the design of the AAV expression construct allows the reproduction of various disease-causing mutations, and also drives neuron-specific expression. The natural and newly created AAV serotypes combined with various delivery routes enable differentially targeting neuronal cell types and brain areas in vivo. Moreover, the same viral vector can be used to reproduce the main features of the disorder in mice, rats, and large laboratory animals such as non-human primates. The current review demonstrates the general principles for the development and use of AAVs in modeling neurological diseases. The latest achievements in AAV-mediated modeling of the common (e.g., Alzheimer’s disease, Parkinson’s disease, ataxias, etc.) and ultra-rare disorders affecting the central nervous system are described. The use of AAVs to create multiple animal models of neurological disorders opens opportunities for studying their mechanisms, understanding the main pathological features, and testing therapeutic approaches. View Full-Text
Keywords: genetic neurological disorders; animal models of human disease; viral vectors; adeno-associated viruses; transgene delivery genetic neurological disorders; animal models of human disease; viral vectors; adeno-associated viruses; transgene delivery
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MDPI and ACS Style

Lunev, E.; Karan, A.; Egorova, T.; Bardina, M. Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects. Biomedicines 2022, 10, 1140. https://doi.org/10.3390/biomedicines10051140

AMA Style

Lunev E, Karan A, Egorova T, Bardina M. Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects. Biomedicines. 2022; 10(5):1140. https://doi.org/10.3390/biomedicines10051140

Chicago/Turabian Style

Lunev, Evgenii, Anna Karan, Tatiana Egorova, and Maryana Bardina. 2022. "Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects" Biomedicines 10, no. 5: 1140. https://doi.org/10.3390/biomedicines10051140

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