Biomolecules, Volume 16, Issue 2
2026 February - 160 articles
Cover Story: Soft tissue sarcoma remains difficult to treat due to heterogeneity, stemness-driven survival, and therapeutic resistance. Extracellular vesicles (EVs) mediate tumor–stroma communication; yet the impact of stemness-targeted therapies on EVs-associated miRNA networks is unclear. EVs miRNA cargo from mesenchymal stem/stromal cells (MSC) and sarcoma cells (SC) were profiled under basal conditions and after treatment with a synthetic tyrosine–peptide analog (TPA). Identified miRNAs regulate oncogenic and regenerative pathways, revealing regulatory nodes in refractory cancers. Pathway analyses indicate the need for functional validation, including macrophage polarization, angiogenesis, and tumor proliferation assays. EVs miRNAs profiling thus provides a framework for developing next-generation therapies for aggressive malignancies. View this paper
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Biomolecules - ISSN 2218-273X