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Review

Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives

1
Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa 58051-900, Brazil
2
Department of Molecular and Cellular Biology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, USA
3
Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil
4
Postgraduate Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Vladimir N. Uversky
Biomolecules 2021, 11(8), 1254; https://doi.org/10.3390/biom11081254
Received: 18 July 2021 / Revised: 14 August 2021 / Accepted: 15 August 2021 / Published: 23 August 2021
(This article belongs to the Special Issue Bioactive Natural Compounds against Animal and Human Pathogens)
In 2019, COVID-19 emerged as a severe respiratory disease that is caused by the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The disease has been associated with high mortality rate, especially in patients with comorbidities such as diabetes, cardiovascular and kidney diseases. This could be attributed to dysregulated immune responses and severe systemic inflammation in COVID-19 patients. The use of effective antiviral drugs against SARS-CoV-2 and modulation of the immune responses could be a potential therapeutic strategy for COVID-19. Studies have shown that natural phenolic compounds have several pharmacological properties, including anticoronavirus and immunomodulatory activities. Therefore, this review discusses the dual action of these natural products from the perspective of applicability at COVID-19. View Full-Text
Keywords: natural products; flavonoid; plants; chalcone; Middle East Respiratory Syndrome Virus; SARS-CoV; MERS-CoV; SARS-CoV-2; COVID-19; viruses natural products; flavonoid; plants; chalcone; Middle East Respiratory Syndrome Virus; SARS-CoV; MERS-CoV; SARS-CoV-2; COVID-19; viruses
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MDPI and ACS Style

Dejani, N.N.; Elshabrawy, H.A.; Bezerra Filho, C.d.S.M.; de Sousa, D.P. Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives. Biomolecules 2021, 11, 1254. https://doi.org/10.3390/biom11081254

AMA Style

Dejani NN, Elshabrawy HA, Bezerra Filho CdSM, de Sousa DP. Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives. Biomolecules. 2021; 11(8):1254. https://doi.org/10.3390/biom11081254

Chicago/Turabian Style

Dejani, Naiara Naiana, Hatem A. Elshabrawy, Carlos da Silva Maia Bezerra Filho, and Damião Pergentino de Sousa. 2021. "Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives" Biomolecules 11, no. 8: 1254. https://doi.org/10.3390/biom11081254

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