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Redox Signaling from Mitochondria: Signal Propagation and Its Targets

Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic
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Biomolecules 2020, 10(1), 93; https://doi.org/10.3390/biom10010093
Received: 6 December 2019 / Revised: 2 January 2020 / Accepted: 2 January 2020 / Published: 6 January 2020
Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations. View Full-Text
Keywords: Redox signaling from mitochondria; mitochondrial superoxide formation; H2O2 diffusion; peroxiredoxins; HIF; redox-regulation of kinases Redox signaling from mitochondria; mitochondrial superoxide formation; H2O2 diffusion; peroxiredoxins; HIF; redox-regulation of kinases
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Ježek, P.; Holendová, B.; Plecitá-Hlavatá, L. Redox Signaling from Mitochondria: Signal Propagation and Its Targets. Biomolecules 2020, 10, 93.

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