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Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

1
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan
2
Research Institute for Electronic Science, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, Japan
3
School of Pharmacy, Institut Teknologi Bandung, Ganesha 10, Bandung 40132, Indonesia
4
Department of Pediatrics, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 83; https://doi.org/10.3390/biom10010083
Received: 4 December 2019 / Revised: 24 December 2019 / Accepted: 1 January 2020 / Published: 5 January 2020
There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress. We also describe cell therapy for reducing oxidative stress in mitochondria. Finally, we discuss the possibilities and problems associated with clinical applications of mitochondrial DDS to regulate mitochondrial oxidative stress. View Full-Text
Keywords: mitochondria; oxidative stress; photodynamic therapy; cancer therapy; antioxidant therapy; cell therapy; drug delivery system; liposomes; MITO-Porter mitochondria; oxidative stress; photodynamic therapy; cancer therapy; antioxidant therapy; cell therapy; drug delivery system; liposomes; MITO-Porter
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MDPI and ACS Style

Yamada, Y.; Takano, Y.; Satrialdi; Abe, J.; Hibino, M.; Harashima, H. Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress. Biomolecules 2020, 10, 83.

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