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Article

2 Citations

1,876 Views

10 Pages

Investigation of the Nanoparticulation Method and Cell-Killing Effect following the Mitochondrial Delivery of Hydrophobic Porphyrin-Based Photosensitizers

Rina Naganawa,
Hanjun Zhao,
Yuta Takano,
Masatoshi Maeki,
Manabu Tokeshi,
Hideyoshi Harashima and
Yuma Yamada

Int. J. Mol. Sci.2024, 25(8), 4294;https://doi.org/10.3390/ijms25084294

12 April 2024

Photodynamic therapy is expected to be a less invasive treatment, and strategies for targeting mitochondria, the main sources of singlet oxygen, are attracting attention to increase the efficacy of photodynamic therapy and reduce its side effects. To...

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Article

1 Citations

2,493 Views

12 Pages

Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States

Yuma Yamada,
Shinnosuke Daikuhara,
Atsushi Tamura,
Kei Nishida,
Nobuhiko Yui and
Hideyoshi Harashima

Biomolecules2023, 13(6), 903;https://doi.org/10.3390/biom13060903

29 May 2023

Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of defective proteins and the formation of abnormal organelles. Methylated β-cyclodextrins-threaded polyrotaxan...

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Article

14 Citations

4,227 Views

12 Pages

Development of a Mitochondrial Targeting Lipid Nanoparticle Encapsulating Berberine

Ikuma Hori,
Hideyoshi Harashima and
Yuma Yamada

Int. J. Mol. Sci.2023, 24(2), 903;https://doi.org/10.3390/ijms24020903

4 January 2023

Delivering drugs to mitochondria, the main source of energy in neurons, can be a useful therapeutic strategy for the treatment of neurodegenerative diseases. Berberine (BBR), an isoquinoline alkaloid, acts on mitochondria and is involved in mechanism...

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Review

60 Citations

10,035 Views

23 Pages

Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

Yuma Yamada,
Yuta Takano,
Satrialdi,
Jiro Abe,
Mitsue Hibino and
Hideyoshi Harashima

Biomolecules2020, 10(1), 83;https://doi.org/10.3390/biom10010083

5 January 2020

There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mit...

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Review

89 Citations

8,429 Views

17 Pages

Challenges in Promoting Mitochondrial Transplantation Therapy

Yuma Yamada,
Momo Ito,
Manae Arai,
Mitsue Hibino,
Takao Tsujioka and
Hideyoshi Harashima

Int. J. Mol. Sci.2020, 21(17), 6365;https://doi.org/10.3390/ijms21176365

2 September 2020

Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has been reported to be useful in the treatment of cardiac ischemic reperfusion injuries in human clinical trials and has als...

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Review

64 Citations

11,081 Views

26 Pages

Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery Systems: Therapeutics for Mitochondrial Disorders

Sakshi Buchke,
Muskan Sharma,
Anusuiya Bora,
Maitrali Relekar,
Piyush Bhanu and
Jitendra Kumar

Life2022, 12(5), 657;https://doi.org/10.3390/life12050657

29 April 2022

Apart from ATP generation, mitochondria are involved in a wide range of functions, making them one of the most prominent organelles of the human cell. Mitochondrial dysfunction is involved in the pathophysiology of several diseases, such as cancer, n...

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