Next Article in Journal
Using Expert Driven Machine Learning to Enhance Dynamic Metabolomics Data Analysis
Next Article in Special Issue
Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study
Previous Article in Journal
Critical Review of Volatile Organic Compound Analysis in Breath and In Vitro Cell Culture for Detection of Lung Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Metabolites
Volume 9
Issue 3
10.3390/metabo9030053
metabolites-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure

by
Mingshu Shi
1,
Øyvind Ellingsen
1,2,*,
Tone Frost Bathen
1,
Morten A. Høydal
1,2,3,
Tomas Stølen
1,2,3,† and
Morteza Esmaeili
1,†
1
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway
2
Clinic of Cardiology, St Olavs Hospital, NO-7491 Trondheim, Norway
3
Clinic of Cardiothoracic Surgery, St Olavs Hospital, NO-7491 Trondheim, Norway
*
Author to whom correspondence should be addressed.
†
These two authors contributed equally to this paper.
Metabolites 2019, 9(3), 53; https://doi.org/10.3390/metabo9030053
Submission received: 22 January 2019 / Revised: 12 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Exercise Metabonomics)
Browse Figures
Review Reports Versions Notes

Abstract

The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in myocardial and skeletal muscle in HF and exercise training using MRS, and thus to identify targets for clinical MRS in vivo. After surgically establishing HF in rats, we randomized the rats to exercise training programs of different intensities. After the final training session, rats were sacrificed and tissues from the myocardial and skeletal muscle were extracted. Magnetic resonance spectra were acquired from these extracts, and principal component and metabolic enrichment analysis were used to assess the differences in metabolic profiles. The results indicated that HF affected myocardial metabolism by changing multiple metabolites, whereas it had a limited effect on skeletal muscle metabolism. Moreover, exercise training mainly altered the metabolite distribution in skeletal muscle, indicating regulation of metabolic pathways of taurine and hypotaurine metabolism and carnitine synthesis.
Keywords: metabolomics; MRS; magnetic resonance spectroscopy; cardiac metabolism metabolomics; MRS; magnetic resonance spectroscopy; cardiac metabolism

Share and Cite

MDPI and ACS Style

Shi, M.; Ellingsen, Ø.; Bathen, T.F.; Høydal, M.A.; Stølen, T.; Esmaeili, M. The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure. Metabolites 2019, 9, 53. https://doi.org/10.3390/metabo9030053

AMA Style

Shi M, Ellingsen Ø, Bathen TF, Høydal MA, Stølen T, Esmaeili M. The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure. Metabolites. 2019; 9(3):53. https://doi.org/10.3390/metabo9030053

Chicago/Turabian Style

Shi, Mingshu, Øyvind Ellingsen, Tone Frost Bathen, Morten A. Høydal, Tomas Stølen, and Morteza Esmaeili. 2019. "The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure" Metabolites 9, no. 3: 53. https://doi.org/10.3390/metabo9030053

APA Style

Shi, M., Ellingsen, Ø., Bathen, T. F., Høydal, M. A., Stølen, T., & Esmaeili, M. (2019). The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure. Metabolites, 9(3), 53. https://doi.org/10.3390/metabo9030053

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop