Review Reports

Round 1

Reviewer 1 Report

The revised version is now suitable for the publication in Metabolites

Author Response

We appreciate it.

Reviewer 2 Report

The revised version of the manuscript has been improved regarding a more elaborate description of the used methodology. Also, previous works using the same database (MGYS00001248) have been cited. However, the article remains merely descriptive, and in the discussion, no new information to correlate the metabolic changes with the angiogenesis, inflammation, mutation rates, have been presented. This is a time-consuming effort, but it needed to highlight the biological meaning of this article. New figures and schemes should be included in the manuscript or the supplemental material (and therefore the number of figures already in place or that is a time-consuming effort do not justify that they are not presented) since they are needed to justify the relevance of the finding presented in the manuscript.

Author Response

Thank you very much. We also agree with your suggestion. Therefore, we created a new figure (Supplementary figure 1) and summarized the main results in that figure.