Phenylpropanoids and Polyacetylenes from Ligusticum mutellina (Apiaceae) of Tyrolean Origin

Roots of Ligusticum mutellina (L.) CRANTZ afforded five major compounds, the phenylpropanoids trans-isoelemicin (1), sarisan (2), and trans-isomyristicin (3), and the polyacetylenes falcarindiol (4) and falcarindiol-3-O-acetate (5). Structures were assigned by 1D- and 2D-NMR spectroscopy. Close inspection of the NMR spectra of falcarindiol-3-O-acetate (5) and comparison with the literature revealed that published NMR data for this compound are most probably attributable to cis or trans Δ2-isofalcarindiol-1-O-acetate (6a/6b). ¹H and ¹³C NMR data for falcarindiol-3-O-acetate are given and trans-isoelemicin (1), sarisan (2), and trans-isomyristicin (3), falcarindiol (4), and falcarindiol-3-O-acetate (5) are reported for the first time from Ligusticum mutellina. Chemosystematic and ethnopharmacological implications of the findings are discussed briefly.