Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

Nakyai, Wongnapa; Pabuprapap, Wachirachai; Sroimee, Wichuda; Ajavakom, Vachiraporn; Yingyongnarongkul, Boon-ek; Suksamrarn, Apichart

doi:10.3390/cosmetics8040107

Open AccessArticle

Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

by

Wongnapa Nakyai

^1,*,

Wachirachai Pabuprapap

¹

,

Wichuda Sroimee

²,

Vachiraporn Ajavakom

¹,

Boon-ek Yingyongnarongkul

¹ and

Apichart Suksamrarn

¹

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand

²

College of Integrative Medicine, Dhurakij Pundit University, Bangkok 10210, Thailand

^*

Author to whom correspondence should be addressed.

Cosmetics 2021, 8(4), 107; https://doi.org/10.3390/cosmetics8040107

Submission received: 5 October 2021 / Revised: 7 November 2021 / Accepted: 8 November 2021 / Published: 12 November 2021

(This article belongs to the Special Issue Green Ingredients in Cosmetics and Food (Volume II))

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Abstract

Acne vulgaris is a common chronic inflammatory skin disease. In the present study, we reported the anti-acne vulgaris effect of the Mesua ferrea (M. ferrea) flower extract. The extract was evaluated for three anti-acne-causing bacteria properties including Cutibacterium acnes (C. acnes), Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus). The results indicated that the M. ferrea flower extract could be considered as the bactericidal agent against S. epidermidis and S. aureus with MIC values of 0.78 and 6.25 mg mL⁻¹ and MBC values of 1.56 and 12.50 mg mL⁻¹ and the bacteriostatic agent against C. acnes with MIC and MBC values of 3.12 and 25.00 mg mL⁻¹, respectively. The extract at a concentration of 25 µg mL⁻¹ also presented potent anti-inflammatory activity with a significant decrease of nitric oxide (NO) and tumor necrosis factor (TNF)-α productions in RAW 264.7 macrophage cells stimulated by LPS. In addition, the extract showed moderate to weak anti-oxidative capacities against DPPH, ABTS, FRAP and NO assays and also showed weak anti-tyrosinase activity. M. ferrea flower extract may serve as the alternative natural anti-acne formulations.

Keywords: Mesua ferrea; anti-acne; anti-bacteria; anti-inflammation; anti-oxidant; anti-tyrosinase

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MDPI and ACS Style

Nakyai, W.; Pabuprapap, W.; Sroimee, W.; Ajavakom, V.; Yingyongnarongkul, B.-e.; Suksamrarn, A. Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers. Cosmetics 2021, 8, 107. https://doi.org/10.3390/cosmetics8040107

AMA Style

Nakyai W, Pabuprapap W, Sroimee W, Ajavakom V, Yingyongnarongkul B-e, Suksamrarn A. Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers. Cosmetics. 2021; 8(4):107. https://doi.org/10.3390/cosmetics8040107

Chicago/Turabian Style

Nakyai, Wongnapa, Wachirachai Pabuprapap, Wichuda Sroimee, Vachiraporn Ajavakom, Boon-ek Yingyongnarongkul, and Apichart Suksamrarn. 2021. "Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers" Cosmetics 8, no. 4: 107. https://doi.org/10.3390/cosmetics8040107

APA Style

Nakyai, W., Pabuprapap, W., Sroimee, W., Ajavakom, V., Yingyongnarongkul, B.-e., & Suksamrarn, A. (2021). Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers. Cosmetics, 8(4), 107. https://doi.org/10.3390/cosmetics8040107

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Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

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