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Article

Characterization, Stability Assessment, Antioxidant Evaluation and Cell Proliferation Activity of Virgin Coconut Oil-based Nanostructured Lipid Carrier Loaded with Ficus deltoidea Extract

1
Institute of Bioproduct Development (IBD), Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, Malaysia
2
International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Gombak 53100, Malaysia
3
Institute of Medical Research (IMR), Jalan Pahang, Kuala Lumpur 50588, Malaysia
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(4), 83; https://doi.org/10.3390/cosmetics7040083
Received: 15 September 2020 / Revised: 12 October 2020 / Accepted: 13 October 2020 / Published: 2 November 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
In this study, the Ficus deltoidea extract loaded nanostructured lipid carrier was prepared by using the melt emulsification homogenization method. Virgin coconut oil is used as liquid lipid, while glyceryl monostearate is the solid lipid. Particle size, zeta potential, entrapment efficiency, drug loading and morphology of the obtained nanostructured lipid carrier (NLC) were measured. The size of the nanostructured lipid carrier incorporated with Ficus deltoidea (FDNLC) is 158.0 ± 1.3 nm, with a polydispersity index of 0.15 ± 0.02. The zeta potential obtained is −42.3 ± 1.5 mV. The encapsulation efficiency and active ingredient loading capacity for FDNLC is 87.4% ± 1.3% and 8.5% ± 1.2%, respectively. The shape of FDNLC is almost spherical and the stability assessment showed that the obtained formulation is at least stable for 40 days. When compared with the positive controls, which are Trolox and ascorbic acid, FDNLC shows the highest antioxidant value. Cell proliferation activity study indicates that FDNLC is not toxic to cells, and FDNLC could potentially treat damage by ultraviolet B (UVB) irradiation. View Full-Text
Keywords: nanostructured lipid carrier (NLC); Ficus deltoidea; virgin coconut oil; characterization; stability; antioxidant nanostructured lipid carrier (NLC); Ficus deltoidea; virgin coconut oil; characterization; stability; antioxidant
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MDPI and ACS Style

Azmi, N.A.N.; Hasham, R.; Ariffin, F.D.; Elgharbawy, A.A.M.; Salleh, H.M. Characterization, Stability Assessment, Antioxidant Evaluation and Cell Proliferation Activity of Virgin Coconut Oil-based Nanostructured Lipid Carrier Loaded with Ficus deltoidea Extract. Cosmetics 2020, 7, 83. https://doi.org/10.3390/cosmetics7040083

AMA Style

Azmi NAN, Hasham R, Ariffin FD, Elgharbawy AAM, Salleh HM. Characterization, Stability Assessment, Antioxidant Evaluation and Cell Proliferation Activity of Virgin Coconut Oil-based Nanostructured Lipid Carrier Loaded with Ficus deltoidea Extract. Cosmetics. 2020; 7(4):83. https://doi.org/10.3390/cosmetics7040083

Chicago/Turabian Style

Azmi, Nor A.N., Rosnani Hasham, Farah D. Ariffin, Amal A.M. Elgharbawy, and Hamzah M. Salleh 2020. "Characterization, Stability Assessment, Antioxidant Evaluation and Cell Proliferation Activity of Virgin Coconut Oil-based Nanostructured Lipid Carrier Loaded with Ficus deltoidea Extract" Cosmetics 7, no. 4: 83. https://doi.org/10.3390/cosmetics7040083

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