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Open AccessArticle

Inhibitory Effect of Manassantin B Isolated from Saururus chinensis on Skin Heat Aging

1
Bio Convergence R&D Center, CoSeedBioPharm Corporation, Heungdeok-gu, Cheongju, Chungbuk 28161, Korea
2
Future Science Research Center, Coreana Cosmetics Corporation, Seobuk-gu, Cheonan, Chungnam 31041, Korea
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 47; https://doi.org/10.3390/cosmetics7020047
Received: 8 May 2020 / Revised: 5 June 2020 / Accepted: 12 June 2020 / Published: 16 June 2020
Heat shock treatment-induced skin aging causes a thickened epidermis, increased matrix metalloproteinase (MMP)-1 expression, collagen degradation, and deep wrinkles. In this study, we investigated the effect of manassantin B in preventing heat shock treatment-induced aging. We first separated manassantin B (MB) from the roots of Saururus chinensis, and the structure was identified using 1H- and 13C-NMR spectroscopy. RT-PCR and western blotting were applied to investigate the anti-aging effect of manassantin B. Manassantin B decreased MMP-1 expression through transient receptor potential vanilloid (TRPV) 1 channel inhibition and significantly increased procollagen expression. In addition, manassantin B suppressed MAPK phosphorylation in a dose-dependent manner. Our results suggest that manassantin B, the active ingredient in S. chinensis, can be effectively used to inhibit heat shock treatment-induced skin aging. View Full-Text
Keywords: saururus chinensis; manassantin B; heat shock; TRPV1; anti-aging activity saururus chinensis; manassantin B; heat shock; TRPV1; anti-aging activity
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Ryu, H.S.; Choi, J.-Y.; Lee, K.-S.; Lee, J.-N.; Lee, C.M.; Park, S.-M. Inhibitory Effect of Manassantin B Isolated from Saururus chinensis on Skin Heat Aging. Cosmetics 2020, 7, 47.

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