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Keywords = manassantin B

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Article
Inhibitory Effect of Manassantin B Isolated from Saururus chinensis on Skin Heat Aging
by Hwa Sun Ryu, Jeong-Yeon Choi, Kyeong-Sun Lee, Jung-No Lee, Chun Mong Lee and Sung-Min Park
Cosmetics 2020, 7(2), 47; https://doi.org/10.3390/cosmetics7020047 - 16 Jun 2020
Cited by 2 | Viewed by 5128
Abstract
Heat shock treatment-induced skin aging causes a thickened epidermis, increased matrix metalloproteinase (MMP)-1 expression, collagen degradation, and deep wrinkles. In this study, we investigated the effect of manassantin B in preventing heat shock treatment-induced aging. We first separated manassantin B (MB) from the [...] Read more.
Heat shock treatment-induced skin aging causes a thickened epidermis, increased matrix metalloproteinase (MMP)-1 expression, collagen degradation, and deep wrinkles. In this study, we investigated the effect of manassantin B in preventing heat shock treatment-induced aging. We first separated manassantin B (MB) from the roots of Saururus chinensis, and the structure was identified using 1H- and 13C-NMR spectroscopy. RT-PCR and western blotting were applied to investigate the anti-aging effect of manassantin B. Manassantin B decreased MMP-1 expression through transient receptor potential vanilloid (TRPV) 1 channel inhibition and significantly increased procollagen expression. In addition, manassantin B suppressed MAPK phosphorylation in a dose-dependent manner. Our results suggest that manassantin B, the active ingredient in S. chinensis, can be effectively used to inhibit heat shock treatment-induced skin aging. Full article
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