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Open AccessArticle

Broussonetia papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

1
Department of Pharmaceutical Science & Engineering, Seowon University, Cheongju 28674, Korea
2
Cosmeceutical R&D Center, Department of Cosmetics, Seowon University, Cheongju 28674, Korea
3
Department of Food Science & Engineering, Seowon University, Cheongju, Chungbuk 28674, Korea
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 40; https://doi.org/10.3390/cosmetics7020040
Received: 13 May 2020 / Revised: 25 May 2020 / Accepted: 28 May 2020 / Published: 1 June 2020
Broussonetia papyrifera (B.papyrifera), belonging to the Moraceae family, is known to elicit anti-inflammatory, antioxidant, anti-tyrosinase, anticancer, antinociceptive, and antimicrobial effects. The present study has been designed to examine the effects of B. papyrifera extract on hair growth through in vitro and clinical samples. Real-time cell growth assay, T-cell factor/lymphoid enhancer-binding factor (TCF/LEF), activation of signal transducer and activator of transcription-6(STAT6) and STAT3 reporter gene function, and Western blotting was performed to examine whether B. papyrifera regulates the expression of target proteins implicated in the proliferation of human hair follicle dermal papilla (hHFDP) cells. In this human trial, using a phototrichogram, the effect of B. papyrifera on hair growth was examined by reconstitution analysis after shaving the hair of the clinical subject’s dorsal skin. B. papyrifera promoted growth equally in hHFDP cells, which is comparable to that of minoxidil and tofacitinib. Treatment with B. papyrifera extract enhanced the TCF/LEF-luciferase activity and increased the level of β-catenin protein. Moreover, B. papyrifera extract significantly suppressed interleukin-4 (IL4)-induced STAT6 phosphorylation. In clinical trial, using a phototrichogram, we assessed the hair density and total hair counts at 0, 6, and 12 weeks after the use of hair tonic containing B. papyrifera extract. After using the hair tonic for 12 weeks, the total hair count was significantly increased as compared with the subjects at the start date (n = 11). B. papyrifera promotes dermal papilla cells proliferation in vitro and clinically among human volunteers through the regulation of WNT-β-catenin and STAT6 pathways. View Full-Text
Keywords: Broussonetia papyrifera; hair growth; WNT-β-catenin; JAK3-STAT6; clinical; phototrichogram Broussonetia papyrifera; hair growth; WNT-β-catenin; JAK3-STAT6; clinical; phototrichogram
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Lee, Y.H.; Nam, G.; Kim, M.-K.; Cho, S.-C.; Choi, B.Y. Broussonetia papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples. Cosmetics 2020, 7, 40.

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