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Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study

1
Innovation and Development, ISDIN S.A., 08019 Barcelona, Spain
2
Dermik. Clínica Dermatológica multidisciplinar, 08019 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Cosmetics 2019, 6(1), 15; https://doi.org/10.3390/cosmetics6010015
Received: 25 January 2019 / Revised: 20 February 2019 / Accepted: 25 February 2019 / Published: 1 March 2019
(This article belongs to the Special Issue Melanogenesis and Melanin-Related Compounds: A Cosmetic Perspective)
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Abstract

Background: Melasma is a common hyperpigmentation disorder, characterized by light-to-dark brown patches, usually distributed on sun-exposed areas of the body. The objective of this study was to evaluate the efficacy and tolerability of an oral nutritional supplement containing Pinus pinaster and Grape seed extract, vitamins and minerals, used concomitantly with a high SPF sunscreen in 30 women with mild-to-moderate facial melasma. Methods: Efficacy was assessed by measurement of the Melasma Area and Severity Index (MASI), instrumental analysis of the lesions (Mexameter®, VISIA®)) and Patient’s and Physician’s Global Assessment (PGA). Results: The MASI score decreased significantly compared with baseline at days 28, 56, and 84. Mexameter® analysis showed a significant decrease of ∆M (difference in the melanin index between melasma and adjacent area). VISIA® results also showed a reduction in the number and areas of UV pigmented spots and in the areas of melasma overtime. Both the Patient’s and Physician’s Global Assessment showed that the product led to an improvement of the lesions in terms of depigmentation and had positive cosmetic features without adverse events. Conclusion: The oral supplement subject of this study in combination with high SPF sunscreen was effective and well-tolerated for treatment of mild to moderate facial melasma. View Full-Text
Keywords: melasma; oral supplement; clinical study; Pinus-pinaster bark extract; grape seed extract melasma; oral supplement; clinical study; Pinus-pinaster bark extract; grape seed extract
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Aladrén, S.; Garre, A.; Valderas-Martínez, P.; Piquero-Casals, J.; Granger, C. Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study. Cosmetics 2019, 6, 15.

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