Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications
AbstractAn electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds. View Full-Text
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Shabunin, A.S.; Yudin, V.E.; Dobrovolskaya, I.P.; Zinovyev, E.V.; Zubov, V.; Ivan’kova, E.M.; Morganti, P. Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications. Cosmetics 2019, 6, 16.
Shabunin AS, Yudin VE, Dobrovolskaya IP, Zinovyev EV, Zubov V, Ivan’kova EM, Morganti P. Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications. Cosmetics. 2019; 6(1):16.Chicago/Turabian Style
Shabunin, Anton S.; Yudin, Vladimir E.; Dobrovolskaya, Irina P.; Zinovyev, Evgeny V.; Zubov, Viktor; Ivan’kova, Elena M.; Morganti, Pierfrancesco. 2019. "Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications." Cosmetics 6, no. 1: 16.
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