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Open AccessArticle

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

Department for Advanced Surface Processing and Analysis by Vacuum Technologies, National Institute of Research and Development for Optoelectronics–INOE 2000, 409 Atomistilor St., RO77125 Magurele, Romania
Physical Materials Science and Composite Materials Centre, National Research Tomsk Polytechnic University, Lenin Avenue 43, Tomsk 634050, Russia
Department of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Spl. Independentei, RO60042 Bucharest, Romania
Author to whom correspondence should be addressed.
Coatings 2019, 9(6), 389;
Received: 13 May 2019 / Revised: 11 June 2019 / Accepted: 13 June 2019 / Published: 15 June 2019
(This article belongs to the Special Issue Surface Modification of Medical Implants)
Considering the requirements of medical implantable devices, it is pointed out that biomaterials should play a more sophisticated, longer-term role in the customization and optimization of the material–tissue interface in order to ensure the best long-term clinical outcomes. The aim of this contribution was to assess the performance of silicon carbide–hydroxyapatite in various simulated biological fluids (Dulbecco’s modified Eagle’s medium (DMEM), simulated body fluid (SBF), and phosphate buffer solution (PBS)) through immersion assays for 21 days at 37 ± 0.5 °C and to evaluate the electrochemical behavior. The coatings were prepared on Ti6Al4V alloy substrates by magnetron sputtering method using two cathodes made of hydroxyapatite and silicon carbide (SiC). After immersion assays the coating’s surface was analyzed in terms of morphology, chemical and phase composition, and chemical bonds. According to the electrochemical behavior in the media investigated at 37 ± 0.5 °C, SiC addition inhibits the dissolution of the hydroxyapatite in DMEM acellular media. Furthermore, after adding SiC, the slow degradation of hydroxyapatite in PBS and SBF media as well as biomineralization in DMEM were observed. View Full-Text
Keywords: SBF; DMEM; PBS; hydroxyapatite; silicon; magnetron sputtering SBF; DMEM; PBS; hydroxyapatite; silicon; magnetron sputtering
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MDPI and ACS Style

Vlădescu, A.; Pârâu, A.; Pană, I.; Cotruț, C.M.; Constantin, L.R.; Braic, V.; Vrânceanu, D.M. In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids. Coatings 2019, 9, 389.

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