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Antibiotics
Volume 9
Issue 6
10.3390/antibiotics9060328
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Article

Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030

by
Manu Singh
1,
P. Malaka De Silva
1,
Yasser Al-Saadi
1,
Jacek Switala
1,
Peter C. Loewen
1,
Georg Hausner
1,
Wangxue Chen
2,
Ismael Hernandez
3,
Santiago Castillo-Ramirez
3 and
Ayush Kumar
1,*
1
Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
2
Human Health Therapeutics, National Research Council Canada, 100 Sussex Drive, Ottawa, ON K1A 0R6, Canada
3
Programa de Genómica Evolutiva, Centro de Ciencias Génomicas, Universidad Nacional Autónoma de México, Cuernavaca 62210, Mexico
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(6), 328; https://doi.org/10.3390/antibiotics9060328
Submission received: 17 May 2020 / Revised: 12 June 2020 / Accepted: 15 June 2020 / Published: 17 June 2020
(This article belongs to the Special Issue Bacterial Pathogens Resistance and Virulence)
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Abstract

Acinetobacter baumannii is an important nosocomial bacterial pathogen. Multidrug-resistant isolates of A. baumannii are reported worldwide. Some A. baumannii isolates display resistance to nearly all antibiotics, making treatment of infections very challenging. As the need for new and effective antibiotics against A. baumannii becomes increasingly urgent, there is a need to understand the mechanisms of antibiotic resistance and virulence in this organism. In this work, comparative genomics was used to understand the mechanisms of antibiotic resistance and virulence in AB030, an extremely drug-resistant and hypervirulent strain of A. baumannii that is a representative of a recently emerged lineage of A. baumannii International Clone V. In order to characterize AB030, we carried out a genomic and phenotypic comparison with LAC-4, a previously described hyper-resistant and hypervirulent isolate. AB030 contains a number of antibiotic resistance- and virulence-associated genes that are not present in LAC-4. A number of these genes are present on mobile elements. This work shows the importance of characterizing the members of new lineages of A. baumannii in order to determine the development of antibiotic resistance and virulence in this organism.
Keywords: multidrug resistance; virulence; gram-negative; comparative genomics; insertion elements multidrug resistance; virulence; gram-negative; comparative genomics; insertion elements

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MDPI and ACS Style

Singh, M.; De Silva, P.M.; Al-Saadi, Y.; Switala, J.; Loewen, P.C.; Hausner, G.; Chen, W.; Hernandez, I.; Castillo-Ramirez, S.; Kumar, A. Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030. Antibiotics 2020, 9, 328. https://doi.org/10.3390/antibiotics9060328

AMA Style

Singh M, De Silva PM, Al-Saadi Y, Switala J, Loewen PC, Hausner G, Chen W, Hernandez I, Castillo-Ramirez S, Kumar A. Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030. Antibiotics. 2020; 9(6):328. https://doi.org/10.3390/antibiotics9060328

Chicago/Turabian Style

Singh, Manu, P. Malaka De Silva, Yasser Al-Saadi, Jacek Switala, Peter C. Loewen, Georg Hausner, Wangxue Chen, Ismael Hernandez, Santiago Castillo-Ramirez, and Ayush Kumar. 2020. "Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030" Antibiotics 9, no. 6: 328. https://doi.org/10.3390/antibiotics9060328

APA Style

Singh, M., De Silva, P. M., Al-Saadi, Y., Switala, J., Loewen, P. C., Hausner, G., Chen, W., Hernandez, I., Castillo-Ramirez, S., & Kumar, A. (2020). Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030. Antibiotics, 9(6), 328. https://doi.org/10.3390/antibiotics9060328

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