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Biosensors 2019, 9(1), 28; https://doi.org/10.3390/bios9010028

Toward Highly Efficient Cancer Imaging and Therapy Using the Environment-Friendly Chitosan Nanoparticles and NIR Laser

1
System and Biomedical Engineering Department, The Higher Institute of Engineering, El Shorouk City, Cairo 11837, Egypt
2
Department of Laser Applications in Metrology, Photochemistry and Agriculture (LAMPA), National Institute of Laser Enhanced Sciences (NILE), Cairo University, Giza 12613, Egypt
3
Department of Engineering Applications of Laser, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, Egypt
4
Cancer Biology Department, Biochemistry and Molecular Biology Unit, National Cancer Institute, Cairo University, Giza 11796, Egypt
*
Author to whom correspondence should be addressed.
Received: 3 January 2019 / Revised: 27 January 2019 / Accepted: 13 February 2019 / Published: 18 February 2019
(This article belongs to the Special Issue Functional Nanomaterials for Biosensing and Bioimaging)
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Abstract

Chitosan-tripolyphosphate nanoparticles (C-TPP NPs) were synthesized to investigate their cytotoxicity against colon cancer cells (Caco2 cells) in the absence and the presence of a near-infrared (NIR) laser to evaluate their influence in cancer detection using the NIR laser and to evaluate the NIR laser on cancer treatment. The synthesized NPs were characterized by Fourier transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), zeta potential (ZP), and transmission electronic microscope (TEM). The cytotoxicity was analyzed by the MTT test and the cell viability was assessed using the Trypan blue method. C-TPP NPs showed increased cytotoxicity and decreased cell viability against Caco2 cells. Upon laser exposure only, the cell viability decreased. The C-TPP NPs appeared to have a shining light on the cancerous cells which were photographed under the inverted microscope. View Full-Text
Keywords: nanoparticles; NIR; Chitosan; cytotoxicity; optical imaging nanoparticles; NIR; Chitosan; cytotoxicity; optical imaging
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Abuelmakarem, H.S.; Sliem, M.A.; El-Azab, J.; Farghaly, M.M.A.; Ahmed, W.A. Toward Highly Efficient Cancer Imaging and Therapy Using the Environment-Friendly Chitosan Nanoparticles and NIR Laser. Biosensors 2019, 9, 28.

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