Next Article in Journal
The Preparation and Properties of Nanocomposite from Bio-Based Polyurethane and Graphene Oxide for Gas Separation
Next Article in Special Issue
Clinical Trials of Thermosensitive Nanomaterials: An Overview
Previous Article in Journal
Pd-Functionalized SnO2 Nanofibers Prepared by Shaddock Peels as Bio-Templates for High Gas Sensing Performance toward Butane
Previous Article in Special Issue
Impact of Quantum Dot Surface on Complex Formation with Chlorin e6 and Photodynamic Therapy
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle

Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells

Department of Chemical Engineering, National Taiwan University, Taipei 103, Taiwan
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(1), 14; https://doi.org/10.3390/nano9010014
Received: 17 November 2018 / Revised: 18 December 2018 / Accepted: 18 December 2018 / Published: 23 December 2018
(This article belongs to the Special Issue Nanomaterials for Photothermal/Photodynamic Therapy)
  |  
PDF [19437 KB, uploaded 23 December 2018]
  |  

Abstract

Methylene blue (MB) is a widely used dye and photodynamic therapy (PDT) agent that can produce reactive oxygen species (ROS) after light exposure, triggering apoptosis. However, it is hard for the dye to penetrate through the cell membrane, leading to poor cellular uptake; thus, drug carriers, which could enhance the cellular uptake, are a suitable solution. In addition, the defective vessels resulting from fast vessel outgrowth leads to an enhanced permeability and retention (EPR) effect, which gives nanoscale drug carriers a promising potential. In this study, we applied poly(12-(methacryloyloxy)dodecyl phosphorylcholine), a zwitterionic polymer-lipid, to self-assemble into liposomes and encapsulate MB (MB-liposome). Its properties of high stability and fast intracellular uptake were confirmed, and the higher in vitro ROS generation ability of MB-liposomes than that of free MB was also verified. For in vivo tests, we examined the toxicity in mice via tail vein injection. With the features found, MB-liposome has the potential of being an effective PDT nano agent for cancer therapy. View Full-Text
Keywords: liposome; methylene blue; breast cancer cell; photodynamic therapy; zwitterion liposome; methylene blue; breast cancer cell; photodynamic therapy; zwitterion
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Wu, P.-T.; Lin, C.-L.; Lin, C.-W.; Chang, N.-C.; Tsai, W.-B.; Yu, J. Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells. Nanomaterials 2019, 9, 14.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top