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Open AccessArticle

Impact of Quantum Dot Surface on Complex Formation with Chlorin e6 and Photodynamic Therapy

1
Biomedical Physics Laboratory, National Cancer Institute, P. Baublio st 3b, LT-08406, Vilnius, Lithuania
2
Life Science Center, Vilnius University, Sauletekio ave. 7, LT-10223 Vilnius, Lithuania
3
Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, Sauletekio ave. 11, LT-10221, Vilnius, Lithuania
4
Biophotonics Group of Laser Research Center, Faculty of Physics, Vilnius University, Sauletekio ave. 9, LT-10222, Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(1), 9; https://doi.org/10.3390/nano9010009
Received: 29 November 2018 / Revised: 16 December 2018 / Accepted: 18 December 2018 / Published: 22 December 2018
(This article belongs to the Special Issue Nanomaterials for Photothermal/Photodynamic Therapy)
Nanomaterials have permeated various fields of scientific research, including that of biomedicine, as alternatives for disease diagnosis and therapy. Among different structures, quantum dots (QDs) have distinctive physico-chemical properties sought after in cancer research and eradication. Within the context of cancer therapy, QDs serve the role of transporters and energy donors to photodynamic therapy (PDT) drugs, extending the applicability and efficiency of classic PDT. In contrast to conventional PDT agents, QDs’ surface can be designed to promote cellular targeting and internalization, while their spectral properties enable better light harvesting and deep-tissue use. Here, we investigate the possibility of complex formation between different amphiphilic coating bearing QDs and photosensitizer chlorin e6 (Ce6). We show that complex formation dynamics are dependent on the type of coating—phospholipids or amphiphilic polymers—as well as on the surface charge of QDs. Förster’s resonant energy transfer occurred in every complex studied, confirming the possibility of indirect Ce6 excitation. Nonetheless, in vitro PDT activity was restricted only to negative charge bearing QD-Ce6 complexes, correlating with better accumulation in cancer cells. Overall, these findings help to better design such and similar complexes, as gained insights can be straightforwardly translated to other types of nanostructures—expanding the palette of possible therapeutic agents for cancer therapy. View Full-Text
Keywords: photodynamic therapy; quantum dots; chlorin e6; energy transfer photodynamic therapy; quantum dots; chlorin e6; energy transfer
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MDPI and ACS Style

Skripka, A.; Dapkute, D.; Valanciunaite, J.; Karabanovas, V.; Rotomskis, R. Impact of Quantum Dot Surface on Complex Formation with Chlorin e6 and Photodynamic Therapy. Nanomaterials 2019, 9, 9.

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