Next Article in Journal
Optical Sensors Based on II-VI Quantum Dots
Previous Article in Journal
Micro-Area Ferroelectric, Piezoelectric and Conductive Properties of Single BiFeO3 Nanowire by Scanning Probe Microscopy
Previous Article in Special Issue
Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells

Clinical Trials of Thermosensitive Nanomaterials: An Overview

Department of Applied Physics, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain
Excellence Research Unit “Modeling Nature” (MNat), University of Granada, 18016 Granada, Spain
Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genova, Italy
Department of Human Anatomy and Embryology, University of Granada, 18016 Granada, Spain
Biopathology and Medicine Regenerative Institute (IBIMER), University of Granada, 18016 Granada, Spain
Biosanitary Institute of Granada (ibs.GRANADA), SAS-Universidad de Granada, 18016 Granada, Spain
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(2), 191;
Received: 30 November 2018 / Revised: 15 January 2019 / Accepted: 30 January 2019 / Published: 2 February 2019
(This article belongs to the Special Issue Nanomaterials for Photothermal/Photodynamic Therapy)
Currently, we are facing increasing demand to develop efficient systems for the detection and treatment of diseases that can realistically improve distinct aspects of healthcare in our society. Sensitive nanomaterials that respond to environmental stimuli can play an important role in this task. In this manuscript, we review the clinical trials carried out to date on thermosensitive nanomaterials, including all those clinical trials in hybrid nanomaterials that respond to other stimuli (e.g., magnetic, infrared radiation, and ultrasound). Specifically, we discuss their use in diagnosis and treatment of different diseases. At present, none of the existing trials focused on diagnosis take advantage of the thermosensitive characteristics of these nanoparticles. Indeed, almost all clinical trials consulted explore the use of Ferumoxytol as a current imaging test enhancer. However, the thermal property is being further exploited in the field of disease treatment, especially for the delivery of antitumor drugs. In this regard, ThermoDox®, based on lysolipid thermally sensitive liposome technology to encapsulate doxorubicin (DOX), is the flagship drug. In this review, we have evidenced the discrepancy existing between the number of published papers in thermosensitive nanomaterials and their clinical use, which could be due to the relative novelty of this area of research; more time is needed to validate it through clinical trials. We have no doubt that in the coming years there will be an explosion of clinical trials related to thermosensitive nanomaterials that will surely help to improve current treatments and, above all, will impact on patients’ quality of life and life expectancy. View Full-Text
Keywords: thermosensitive nanomaterials; USPIO; magnetic nanoparticles; Ferumoxytol; gold nanoparticles; ThermoDox thermosensitive nanomaterials; USPIO; magnetic nanoparticles; Ferumoxytol; gold nanoparticles; ThermoDox
Show Figures

Graphical abstract

MDPI and ACS Style

Nardecchia, S.; Sánchez-Moreno, P.; de Vicente, J.; Marchal, J.A.; Boulaiz, H. Clinical Trials of Thermosensitive Nanomaterials: An Overview. Nanomaterials 2019, 9, 191.

AMA Style

Nardecchia S, Sánchez-Moreno P, de Vicente J, Marchal JA, Boulaiz H. Clinical Trials of Thermosensitive Nanomaterials: An Overview. Nanomaterials. 2019; 9(2):191.

Chicago/Turabian Style

Nardecchia, Stefania, Paola Sánchez-Moreno, Juan de Vicente, Juan A. Marchal, and Houria Boulaiz. 2019. "Clinical Trials of Thermosensitive Nanomaterials: An Overview" Nanomaterials 9, no. 2: 191.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop