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Article

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

1
Laboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland
2
Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Giza 12622, Egypt
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Centre for Advanced Materials and Technologies, Warsaw University of Technology, Poleczki 19, 02822 Warsaw, Poland
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Faculty of Materials Science and Engineering, Warsaw University of Technology, 141 Woloska Street, 02507 Warsaw, Poland
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Department of Microbiology, Prof. Wacław Dąbrowski Institute of Agriculture and Food Biotechnology–State Research Institute, 36 Rakowiecka Street, 02532 Warsaw, Poland
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High Pressure Food and Soft Matter Processing Group, Institute of High-Pressure Physics, Polish Academy of Sciences, 29/37 Sokołowska Street, 01142 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Academic Editors: Vi-Khanh Truong and Constantine D. Stalikas
Nanomaterials 2021, 11(7), 1690; https://doi.org/10.3390/nano11071690
Received: 15 May 2021 / Revised: 9 June 2021 / Accepted: 14 June 2021 / Published: 28 June 2021
(This article belongs to the Special Issue Antibacterial Nanomaterials Coating: Fabrication and Applications)
Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants. View Full-Text
Keywords: antibacterial coating; hydroxyapatite nanoparticles; sonocoating; PEEK implants; cefuroxime sodium salt antibiotic; drug release; Staphylococcus aureus bacteria antibacterial coating; hydroxyapatite nanoparticles; sonocoating; PEEK implants; cefuroxime sodium salt antibiotic; drug release; Staphylococcus aureus bacteria
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MDPI and ACS Style

AbouAitah, K.; Bil, M.; Pietrzykowska, E.; Szałaj, U.; Fudala, D.; Woźniak, B.; Nasiłowska, J.; Swiderska-Sroda, A.; Lojkowski, M.; Sokołowska, B.; Swieszkowski, W.; Lojkowski, W. Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method. Nanomaterials 2021, 11, 1690. https://doi.org/10.3390/nano11071690

AMA Style

AbouAitah K, Bil M, Pietrzykowska E, Szałaj U, Fudala D, Woźniak B, Nasiłowska J, Swiderska-Sroda A, Lojkowski M, Sokołowska B, Swieszkowski W, Lojkowski W. Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method. Nanomaterials. 2021; 11(7):1690. https://doi.org/10.3390/nano11071690

Chicago/Turabian Style

AbouAitah, Khaled, Monika Bil, Elzbieta Pietrzykowska, Urszula Szałaj, Damian Fudala, Bartosz Woźniak, Justyna Nasiłowska, Anna Swiderska-Sroda, Maciej Lojkowski, Barbara Sokołowska, Wojciech Swieszkowski, and Witold Lojkowski. 2021. "Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method" Nanomaterials 11, no. 7: 1690. https://doi.org/10.3390/nano11071690

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