Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

Laboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland

Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Giza 12622, Egypt

Centre for Advanced Materials and Technologies, Warsaw University of Technology, Poleczki 19, 02822 Warsaw, Poland

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Faculty of Materials Science and Engineering, Warsaw University of Technology, 141 Woloska Street, 02507 Warsaw, Poland

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Department of Microbiology, Prof. Wacław Dąbrowski Institute of Agriculture and Food Biotechnology–State Research Institute, 36 Rakowiecka Street, 02532 Warsaw, Poland

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High Pressure Food and Soft Matter Processing Group, Institute of High-Pressure Physics, Polish Academy of Sciences, 29/37 Sokołowska Street, 01142 Warsaw, Poland

Authors to whom correspondence should be addressed.

Academic Editors: Vi-Khanh Truong and Constantine D. Stalikas

Nanomaterials 2021, 11(7), 1690; https://doi.org/10.3390/nano11071690

Received: 15 May 2021 / Revised: 9 June 2021 / Accepted: 14 June 2021 / Published: 28 June 2021

(This article belongs to the Special Issue Antibacterial Nanomaterials Coating: Fabrication and Applications)

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Abstract

Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm² of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants. View Full-Text

Keywords: antibacterial coating; hydroxyapatite nanoparticles; sonocoating; PEEK implants; cefuroxime sodium salt antibiotic; drug release; Staphylococcus aureus bacteria

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MDPI and ACS Style

AbouAitah, K.; Bil, M.; Pietrzykowska, E.; Szałaj, U.; Fudala, D.; Woźniak, B.; Nasiłowska, J.; Swiderska-Sroda, A.; Lojkowski, M.; Sokołowska, B.; Swieszkowski, W.; Lojkowski, W. Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method. Nanomaterials 2021, 11, 1690. https://doi.org/10.3390/nano11071690

AMA Style

AbouAitah K, Bil M, Pietrzykowska E, Szałaj U, Fudala D, Woźniak B, Nasiłowska J, Swiderska-Sroda A, Lojkowski M, Sokołowska B, Swieszkowski W, Lojkowski W. Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method. Nanomaterials. 2021; 11(7):1690. https://doi.org/10.3390/nano11071690

Chicago/Turabian Style

AbouAitah, Khaled, Monika Bil, Elzbieta Pietrzykowska, Urszula Szałaj, Damian Fudala, Bartosz Woźniak, Justyna Nasiłowska, Anna Swiderska-Sroda, Maciej Lojkowski, Barbara Sokołowska, Wojciech Swieszkowski, and Witold Lojkowski. 2021. "Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method" Nanomaterials 11, no. 7: 1690. https://doi.org/10.3390/nano11071690

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Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

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