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Open AccessArticle

Synergetic Effect of 2-Methacryloyloxyethyl Phosphorylcholine and Mesoporous Bioactive Glass Nanoparticles on Antibacterial and Anti-Demineralisation Properties in Orthodontic Bonding Agents

1
Department of Orthodontics, Dental Research Institute, Pusan National University, Yangsan 50612, Korea
2
School of Materials Science and Engineering, Pusan National University, Busan 46241, Korea
3
Dental and Life Science Institute, Pusan National University, Yangsan 50612, Korea
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(7), 1282; https://doi.org/10.3390/nano10071282
Received: 25 May 2020 / Revised: 26 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Synthesis and Application of Antimicrobial Nanomaterials)
2-methacryloyloxyethyl phosphorylcholine (MPC) is known to have antibacterial and protein-repellent effects, whereas mesoporous bioactive glass nanoparticles (MBN) are known to have remineralisation effects. We evaluated the antibacterial and remineralisation effects of mixing MPC and MBN at various ratios with orthodontic bonding agents. MPC and MBN were mixed in the following weight percentages in CharmFil-Flow (CF): CF, 3% MPC, 5% MPC, 3% MPC + 3% MBN, and 3% MPC + 5% MBN. As the content of MPC and MBN increased, the mechanical properties of the resin decreased. At 5% MPC, the mechanical properties decreased significantly with respect to CF (shear bond strength), gelation of MPC occurred, and no significant difference was observed in terms of protein adsorption compared to the control group. Composition 3% MPC + 5% MBN exhibited the lowest protein adsorption because the proportion of hydrophobic resin composite decreased; CF (91.8 ± 4.8 μg/mL), 3% MPC (73.9 ± 2.6 μg/mL), 3% MPC + 3% MBN (69.4 ± 3.6 μg/mL), and 3% MPC + 5% MBN (55.9 ± 1.6 μg/mL). In experiments against S. mutans and E. coli, addition of MPC and MBN resulted in significant antibacterial effects. In another experiment, the anti-demineralisation effect was improved when MPC was added, and when MBN was additionally added, it resulted in a synergetic effect. When MPC and MBN were added at an appropriate ratio to the orthodontic bonding agents, the protein-repellent, antibacterial, and anti-demineralisation effects were improved. This combination could thus be an alternative way of treating white spot lesions. View Full-Text
Keywords: mesoporous bioactive glass; 2-methacryloyloxyethyl phosphorylcholine; anti-demineralisation; antibacterial; orthodontic bonding agent mesoporous bioactive glass; 2-methacryloyloxyethyl phosphorylcholine; anti-demineralisation; antibacterial; orthodontic bonding agent
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Park, S.Y.; Yoo, K.-H.; Yoon, S.-Y.; Son, W.-S.; Kim, Y.-I. Synergetic Effect of 2-Methacryloyloxyethyl Phosphorylcholine and Mesoporous Bioactive Glass Nanoparticles on Antibacterial and Anti-Demineralisation Properties in Orthodontic Bonding Agents. Nanomaterials 2020, 10, 1282.

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