Next Article in Journal
Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group
Next Article in Special Issue
Exploration of Functional Connectivity Changes Previously Reported in Fibromyalgia and Their Relation to Psychological Distress and Pain Measures
Previous Article in Journal
Obesity and Pancreatic Cancer: A Matched-Pair Survival Analysis
Previous Article in Special Issue
Effects of COMT Genotypes on Working Memory Performance in Fibromyalgia Patients
Article

Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance

1
Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, SE 581 83 Linköping, Sweden
2
Center for Medical Image Science and Visualization (CMIV), Linköping University, SE 581 83 Linköping, Sweden
3
Radiation Physics, Department of Health, Medicine and Caring Sciences, Linköping University, SE 581 83 Linköping, Sweden
4
Radiation Physics, Department of Health, Medicine and Caring Sciences, SE 581 83 Linköping University & Department of Radiation Physics, UHL, SE 581 85 Linköping, Sweden
5
AMRA Medical AB, SE 582 22 Linköping, Sweden
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3527; https://doi.org/10.3390/jcm9113527
Received: 10 October 2020 / Revised: 28 October 2020 / Accepted: 30 October 2020 / Published: 31 October 2020
In fibromyalgia (FM) muscle metabolism, studies are sparse and conflicting associations have been found between muscle metabolism and pain aspects. This study compared alterations in metabolic substances and blood flow in erector spinae and trapezius of FM patients and healthy controls. FM patients (n = 33) and healthy controls (n = 31) underwent a clinical examination that included pressure pain thresholds and physical tests, completion of a health questionnaire, participation in microdialysis investigations of the etrapezius and erector spinae muscles, and also underwent phosphorus-31 magnetic resonance spectroscopy of the erector spinae muscle. At the baseline, FM had significantly higher levels of pyruvate in both muscles. Significantly lower concentrations of phosphocreatine (PCr) and nucleotide triphosphate (mainly adenosine triphosphate) in erector spinae were found in FM. Blood flow in erector spinae was significantly lower in FM. Significant associations between metabolic variables and pain aspects (pain intensity and pressure pain threshold PPT) were found in FM. Our results suggest that FM has mitochondrial dysfunction, although it is unclear whether inactivity, obesity, aging, and pain are causes of, the results of, or coincidental to the mitochondrial dysfunction. The significant regressions of pain intensity and PPT in FM agree with other studies reporting associations between peripheral biological factors and pain aspects. View Full-Text
Keywords: fibromyalgia; chronic pain; muscle; microdialysis; ATP; PCr; magnetic resonance spectroscopy; magnetic resonance imaging fibromyalgia; chronic pain; muscle; microdialysis; ATP; PCr; magnetic resonance spectroscopy; magnetic resonance imaging
Show Figures

Figure 1

MDPI and ACS Style

Gerdle, B.; Ghafouri, B.; Lund, E.; Bengtsson, A.; Lundberg, P.; Ettinger-Veenstra, H.v.; Leinhard, O.D.; Forsgren, M.F. Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance. J. Clin. Med. 2020, 9, 3527. https://doi.org/10.3390/jcm9113527

AMA Style

Gerdle B, Ghafouri B, Lund E, Bengtsson A, Lundberg P, Ettinger-Veenstra Hv, Leinhard OD, Forsgren MF. Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance. Journal of Clinical Medicine. 2020; 9(11):3527. https://doi.org/10.3390/jcm9113527

Chicago/Turabian Style

Gerdle, Björn, Bijar Ghafouri, Eva Lund, Ann Bengtsson, Peter Lundberg, Helene v. Ettinger-Veenstra, Olof D. Leinhard, and Mikael F. Forsgren. 2020. "Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance" Journal of Clinical Medicine 9, no. 11: 3527. https://doi.org/10.3390/jcm9113527

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop