Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance

Gerdle, Björn; Ghafouri, Bijar; Lund, Eva; Bengtsson, Ann; Lundberg, Peter; Ettinger-Veenstra, Helene van; Leinhard, Olof Dahlqvist; Forsgren, Mikael Fredrik

doi:10.3390/jcm9113527

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Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance

^1,2,*

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¹,

^2,4

Helene van Ettinger-Veenstra

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Olof Dahlqvist Leinhard

^2,4,5 and

Mikael Fredrik Forsgren

^2,4,5

Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, SE 581 83 Linköping, Sweden

Center for Medical Image Science and Visualization (CMIV), Linköping University, SE 581 83 Linköping, Sweden

Radiation Physics, Department of Health, Medicine and Caring Sciences, Linköping University, SE 581 83 Linköping, Sweden

⁴

Radiation Physics, Department of Health, Medicine and Caring Sciences, SE 581 83 Linköping University & Department of Radiation Physics, UHL, SE 581 85 Linköping, Sweden

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AMRA Medical AB, SE 582 22 Linköping, Sweden

Author to whom correspondence should be addressed.

J. Clin. Med. 2020, 9(11), 3527; https://doi.org/10.3390/jcm9113527

Received: 10 October 2020 / Revised: 28 October 2020 / Accepted: 30 October 2020 / Published: 31 October 2020

(This article belongs to the Special Issue New Frontiers in the Diagnosis, Prediction, Prevention, and Management of Fibromyalgia)

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Abstract

In fibromyalgia (FM) muscle metabolism, studies are sparse and conflicting associations have been found between muscle metabolism and pain aspects. This study compared alterations in metabolic substances and blood flow in erector spinae and trapezius of FM patients and healthy controls. FM patients (n = 33) and healthy controls (n = 31) underwent a clinical examination that included pressure pain thresholds and physical tests, completion of a health questionnaire, participation in microdialysis investigations of the etrapezius and erector spinae muscles, and also underwent phosphorus-31 magnetic resonance spectroscopy of the erector spinae muscle. At the baseline, FM had significantly higher levels of pyruvate in both muscles. Significantly lower concentrations of phosphocreatine (PCr) and nucleotide triphosphate (mainly adenosine triphosphate) in erector spinae were found in FM. Blood flow in erector spinae was significantly lower in FM. Significant associations between metabolic variables and pain aspects (pain intensity and pressure pain threshold PPT) were found in FM. Our results suggest that FM has mitochondrial dysfunction, although it is unclear whether inactivity, obesity, aging, and pain are causes of, the results of, or coincidental to the mitochondrial dysfunction. The significant regressions of pain intensity and PPT in FM agree with other studies reporting associations between peripheral biological factors and pain aspects. View Full-Text

Keywords: fibromyalgia; chronic pain; muscle; microdialysis; ATP; PCr; magnetic resonance spectroscopy; magnetic resonance imaging

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Gerdle, B.; Ghafouri, B.; Lund, E.; Bengtsson, A.; Lundberg, P.; Ettinger-Veenstra, H.v.; Leinhard, O.D.; Forsgren, M.F. Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance. J. Clin. Med. 2020, 9, 3527. https://doi.org/10.3390/jcm9113527

AMA Style

Gerdle B, Ghafouri B, Lund E, Bengtsson A, Lundberg P, Ettinger-Veenstra Hv, Leinhard OD, Forsgren MF. Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance. Journal of Clinical Medicine. 2020; 9(11):3527. https://doi.org/10.3390/jcm9113527

Chicago/Turabian Style

Gerdle, Björn, Bijar Ghafouri, Eva Lund, Ann Bengtsson, Peter Lundberg, Helene v. Ettinger-Veenstra, Olof D. Leinhard, and Mikael F. Forsgren. 2020. "Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance" Journal of Clinical Medicine 9, no. 11: 3527. https://doi.org/10.3390/jcm9113527

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Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance

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