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Identification of Potentially Pathogenic Variants Associated with Recurrence in Medication-Related Osteonecrosis of the Jaw (MRONJ) Patients Using Whole-Exome Sequencing
Article

Effects of Type 2 Diabetes Mellitus on Osteoclast Differentiation, Activity, and Cortical Bone Formation in POSTmenopausal MRONJ Patients

Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea
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Author to whom correspondence should be addressed.
Academic Editors: Amerigo Giudice, Francesco Bennardo and Alessandro Antonelli
J. Clin. Med. 2022, 11(9), 2377; https://doi.org/10.3390/jcm11092377
Received: 30 March 2022 / Revised: 20 April 2022 / Accepted: 21 April 2022 / Published: 23 April 2022
(This article belongs to the Special Issue Breakthroughs in Oral and Maxillofacial Surgery)
Osteoporosis is a common metabolic bone disease in patients with diabetes, which can develop simultaneously with type 2 diabetes (T2D) in postmenopausal women. Bisphosphonate (BP) is administered to patients with both conditions and may cause medication-related osteonecrosis of the jaw (MRONJ). It affects the differentiation and function of osteoclasts as well as the thickness of the cortical bone through bone mineralization. Therefore, this study aimed to investigate the effects of T2D on osteoclast differentiation and activity as well as cortical bone formation in postmenopausal patients with MRONJ. Tissue samples were collected from 10 patients diagnosed with T2D and stage III MRONJ in the experimental group and from 10 patients without T2D in the control group. A histological examination was conducted, and the expression of dendritic cell-specific transmembrane protein (DC-STAMP) and tartrate-resistant acid phosphatase (TRAP) was assessed. Cortical bone formation was analyzed using CBCT images. The number of TRAP-positive osteoclasts and DC-STAMP-positive mononuclear cells was significantly less in the experimental group (p < 0.05). Furthermore, the thickness and ratio of cortical bone were significantly greater in the experimental group (p < 0.05). In conclusion, T2D decreased the differentiation and function of osteoclasts and increased cortical bone formation in postmenopausal patients with MRONJ. View Full-Text
Keywords: type 2 diabetes; osteoporosis; bisphosphonate; MRONJ; osteoclast type 2 diabetes; osteoporosis; bisphosphonate; MRONJ; osteoclast
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MDPI and ACS Style

Park, S.-M.; Lee, J.-H. Effects of Type 2 Diabetes Mellitus on Osteoclast Differentiation, Activity, and Cortical Bone Formation in POSTmenopausal MRONJ Patients. J. Clin. Med. 2022, 11, 2377. https://doi.org/10.3390/jcm11092377

AMA Style

Park S-M, Lee J-H. Effects of Type 2 Diabetes Mellitus on Osteoclast Differentiation, Activity, and Cortical Bone Formation in POSTmenopausal MRONJ Patients. Journal of Clinical Medicine. 2022; 11(9):2377. https://doi.org/10.3390/jcm11092377

Chicago/Turabian Style

Park, Sung-Min, and Jae-Hoon Lee. 2022. "Effects of Type 2 Diabetes Mellitus on Osteoclast Differentiation, Activity, and Cortical Bone Formation in POSTmenopausal MRONJ Patients" Journal of Clinical Medicine 11, no. 9: 2377. https://doi.org/10.3390/jcm11092377

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