Review Reports
- Catarina Izidoro1,2,*,
- João Botelho1,2 and
- Vanessa Machado1,2
- et al.
Reviewer 1: Anonymous Reviewer 2: Anonymous Reviewer 3: Nicola De Angelis
Round 1
Reviewer 1 Report
Dear Authors,
The article: Periodontitis, halitosis and oral health-related quality of life – a cross-sectional study was to explore the association between VSCs with PISA and PESA on a cohort of periodontitis patients. We further assessed whether measures of halitosis (VSCs and self-reported) were associated with OHRQoL.
Abstract should be unstructurized.
Punctuation and editorial errors in the text should be corrected.
line 144 slip to another page.
Figure 2 - onclude figure with better quality.
Incorrect citation record type at reference point.
e.g.: Zhang, J.; Yu, X.; Guo, P.; Firrman, J.; Pouchnik, D.; Diao, Y.; Samulski, R.J.; Xiao, W. Satellite Subgenomic Particles Are Key Regulators of Adeno-Associated Virus Life Cycle. Viruses 2021, 13, 1185.
To sum up, article can be accepted after minor revision.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
References from 43 until 50 needs reconsiderations!
Very interesting topic, sample size is a bit tiny. I suggest revising the references, and also having a language editing service.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Reviewer 3 Report
Dear Authors, your work is well conducted and very precise. As clinician periodontist, after reading the article, I asked to myself : will this finding improve my tools for motivation?
I believe that this is a crucial stage with periodontally compromised patients! In details reading table 2 in the results section it can be perceived that for ex. halitosis was detected with similar value in different patients typologies ( who do or do not brush regularly their teeth). Moreover, reported BOP values are 20.9 and 19.9 in patients without and with halitosis respectively; this last consideration may arise a further question " if the halitosis is not directly related to the clinical evolution of the periodontal disease , how can I use it to motivate a patient?".
To conclude, I believe that it a very good exercise of collecting data for a statistical analysis but it may not improve significantly the clinical tools for the everyday practice.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Round 2
Reviewer 3 Report
Dear Authors, thank you for providing answers to my objections. As I said before this research is conducted properly and precisely but it is still far away from clinical application.