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Review

Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment

1
Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia
2
School of Human Sciences, University of Western Australia, Perth, WA 6009, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Adam J. Lewandowski
J. Clin. Med. 2021, 10(17), 3896; https://doi.org/10.3390/jcm10173896
Received: 29 July 2021 / Revised: 26 August 2021 / Accepted: 26 August 2021 / Published: 30 August 2021
Preterm birth coincides with a key developmental window of cardiac growth and maturation, and thus has the potential to influence long-term cardiac function. Individuals born preterm have structural cardiac remodelling and altered cardiac growth and function by early adulthood. The evidence linking preterm birth and cardiovascular disease in later life is mounting. Advances in the perinatal care of preterm infants, such as glucocorticoid therapy, have improved survival rates, but at what cost? This review highlights the short-term and long-term impact of preterm birth on the structure and function of the heart and focuses on the impact of antenatal and postnatal glucocorticoid treatment on the immature preterm heart. View Full-Text
Keywords: infant; preterm; cardiac development; cardiomyocyte; developmental programming; antenatal corticosteroids; postnatal steroids; glucocorticoids infant; preterm; cardiac development; cardiomyocyte; developmental programming; antenatal corticosteroids; postnatal steroids; glucocorticoids
MDPI and ACS Style

Vrselja, A.; Pillow, J.J.; Black, M.J. Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment. J. Clin. Med. 2021, 10, 3896. https://doi.org/10.3390/jcm10173896

AMA Style

Vrselja A, Pillow JJ, Black MJ. Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment. Journal of Clinical Medicine. 2021; 10(17):3896. https://doi.org/10.3390/jcm10173896

Chicago/Turabian Style

Vrselja, Amanda, J. J. Pillow, and M. J. Black. 2021. "Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment" Journal of Clinical Medicine 10, no. 17: 3896. https://doi.org/10.3390/jcm10173896

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