Next Article in Journal
Different Strategies of Preimplantation Genetic Testing for Aneuploidies in Women of Advanced Maternal Age: A Systematic Review and Meta-Analysis
Previous Article in Journal
Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment
Article

Erythema Increase Predicts Psoriasis Improvement after Phototherapy

1
Dermatology Department, Hospital Universitario Virgen de las Nieves, Avenida de Madrid, 15, 18012 Granada, Spain
2
Instituto de Investigación Biosanitaria GRANADA, 18012 Granada, Spain
3
Dermatology Department, Faculty of Medicine, University of Granada, 18001 Granada, Spain
4
Epidemiology and Public Health Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Masutaka Furue
J. Clin. Med. 2021, 10(17), 3897; https://doi.org/10.3390/jcm10173897
Received: 16 July 2021 / Revised: 1 August 2021 / Accepted: 26 August 2021 / Published: 30 August 2021
(This article belongs to the Section Dermatology)
Psoriasis is a major global health problem. There is a need to develop techniques to help physicians select the most appropriate cost-effective therapy for each patient. The main objectives of this study are (1) to evaluate changes in epidermal barrier function and skin homeostasis after phototherapy and (2) to explore potentially predictive values in epidermal barrier function and skin homeostasis to assess clinical improvement after fifteen sessions of phototherapy. A total of 76 subjects, 38 patients with plaque-type psoriasis and 38 gender- and age-matched healthy volunteers, were included in the study. Erythema, transepidermal water loss (TEWL), temperature, stratum corneum hydration (SCH), pH, sebum, and antioxidant capacity were measured before and after the first and fifteenth phototherapy session. Erythema (401.09 vs. 291.12 vs. 284.52 AU, p < 0.001) and TEWL (18.23 vs. 11.44 vs. 11.41 g·m−2·h−1, p < 0.001) were significantly higher at psoriatic plaques than in uninvolved psoriatic skin and healthy volunteers, respectively, while SCH was lower (9.71 vs. 44.64 vs. 40.00 AU, p < 0.001). After fifteen phototherapy sessions, TEWL (–5.19 g·m−2·h−1, p = 0.016) decreased while SCH (+7.01 AU, p = 0.013) and erythema (+30.82 AU, p = 0.083) increased at psoriatic plaques. An erythema increase exceeding 53.23 AU after the first phototherapy session, with a sensitivity of 71.4% and specificity of 84.2%, indicates that a patient may improve Psoriasis Area and Severity Index (PASI) by ≥3 points after fifteen phototherapy sessions. In conclusion, phototherapy improves epidermal barrier function in psoriatic patients and the erythema increase after one phototherapy session could help doctors select psoriasis patients who are more likely to respond to phototherapy. View Full-Text
Keywords: phototherapy; psoriasis; skin barrier; skin physiology; skin homeostasis phototherapy; psoriasis; skin barrier; skin physiology; skin homeostasis
Show Figures

Figure 1

MDPI and ACS Style

Montero-Vilchez, T.; Martinez-Lopez, A.; Sierra-Sanchez, A.; Soler-Gongora, M.; Jimenez-Mejias, E.; Molina-Leyva, A.; Buendia-Eisman, A.; Arias-Santiago, S. Erythema Increase Predicts Psoriasis Improvement after Phototherapy. J. Clin. Med. 2021, 10, 3897. https://doi.org/10.3390/jcm10173897

AMA Style

Montero-Vilchez T, Martinez-Lopez A, Sierra-Sanchez A, Soler-Gongora M, Jimenez-Mejias E, Molina-Leyva A, Buendia-Eisman A, Arias-Santiago S. Erythema Increase Predicts Psoriasis Improvement after Phototherapy. Journal of Clinical Medicine. 2021; 10(17):3897. https://doi.org/10.3390/jcm10173897

Chicago/Turabian Style

Montero-Vilchez, Trinidad, Antonio Martinez-Lopez, Alvaro Sierra-Sanchez, Miguel Soler-Gongora, Eladio Jimenez-Mejias, Alejandro Molina-Leyva, Agustin Buendia-Eisman, and Salvador Arias-Santiago. 2021. "Erythema Increase Predicts Psoriasis Improvement after Phototherapy" Journal of Clinical Medicine 10, no. 17: 3897. https://doi.org/10.3390/jcm10173897

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop