Next Article in Journal
Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment
Next Article in Special Issue
Vaccination for Respiratory Infections in Patients with Heart Failure
Previous Article in Journal
Subjective and Electroencephalographic Sleep Parameters in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review
Previous Article in Special Issue
The Effects of Calculated Remnant-Like Particle Cholesterol on Incident Cardiovascular Disease: Insights from a General Chinese Population
Brief Report

Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation

1
Department of Cardiology, University Hospital of Nancy, 54000 Nancy, France
2
Université de Lorraine, Inserm, Centre d’Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, 54000 Nancy, France
3
Département de Cardiologie & CIC-IT U 804, Centre Hospitalier Universitaire de Rennes, 35033 Rennes, France
*
Author to whom correspondence should be addressed.
Academic Editor: François Roubille
J. Clin. Med. 2021, 10(17), 3894; https://doi.org/10.3390/jcm10173894
Received: 5 August 2021 / Revised: 18 August 2021 / Accepted: 25 August 2021 / Published: 30 August 2021
(This article belongs to the Special Issue Cardiovascular Disease: Risk Factors, Comorbidities, and Prevention)
Background: Atrial fibrillation (AF) leads to the development of cardiac remodeling/diastolic dysfunction and vice versa. We intended to determine whether cardiac remodeling/diastolic dysfunction is present at early stages of AF. Methods: We studied 175 patients with paroxysmal AF, compared with 175 matched control subjects, who had available echocardiography data to investigate the association between echocardiographic variables and AF from the STANISLAS cohort. Results: In this study (mean age 55 years; 70.3% male), patients with paroxysmal AF had greater left ventricular mass compared to matched controls (p < 0.05). Patients with paroxysmal AF were also likely to have larger left atrial volume and a higher peak tricuspid regurgitation velocity, leading to higher prevalence (though <10% in the AF group) of diastolic dysfunction (all-p < 0.05). Multivariable conditional logistic regression models showed that paroxysmal AF was significantly associated with increased left ventricular mass and left atrial enlargement (all-p < 0.001), but not with e’ and deceleration time of E wave (all-p > 0.1). Conclusions: Left ventricular mass and left atrial enlargement rather than diastolic dysfunction (as evaluated by echocardiography) were associated with paroxysmal AF irrespective of body mass index, blood pressure and renal function. These findings suggest that cardiac remodeling may occur very early in the natural history of AF. View Full-Text
Keywords: atrial fibrillation; diastolic dysfunction; left atrial remodeling; echocardiography; heart failure atrial fibrillation; diastolic dysfunction; left atrial remodeling; echocardiography; heart failure
MDPI and ACS Style

Noirclerc, N.; Huttin, O.; de Chillou, C.; Selton-Suty, C.; Fillipetti, L.; Sellal, J.M.; Bozec, E.; Donal, E.; Lamiral, Z.; Kobayashi, M.; Ferreira, J.P.; Rossignol, P.; Girerd, N. Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation. J. Clin. Med. 2021, 10, 3894. https://doi.org/10.3390/jcm10173894

AMA Style

Noirclerc N, Huttin O, de Chillou C, Selton-Suty C, Fillipetti L, Sellal JM, Bozec E, Donal E, Lamiral Z, Kobayashi M, Ferreira JP, Rossignol P, Girerd N. Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation. Journal of Clinical Medicine. 2021; 10(17):3894. https://doi.org/10.3390/jcm10173894

Chicago/Turabian Style

Noirclerc, Nathalie, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean M. Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, João P. Ferreira, Patrick Rossignol, and Nicolas Girerd. 2021. "Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation" Journal of Clinical Medicine 10, no. 17: 3894. https://doi.org/10.3390/jcm10173894

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop